|Related Categories||Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application,|
For the production of positively supercoiled plasmid DNA.1 Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase.4 Inhibitor of retrovirus RNA-dependent DNA-polymerase.5
Novobiocin is used to study heat shock protein inhibition and to produce positively supercoiled plasmid DNA.1. ≥90% (HPLC)
Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II.
Antimicrobial spectrum: Gram-positive bacterial.
Novobiocin inhibits DNA synthesis by inhibiting bacterial DNA gyrase targeting the GyrB subunit of the enzyme involved in energy transduction. Novobiocin acts as a competitive inhibitors of the ATPase reaction catalysed by GyrB 2. It is also a Hsp90 inhibitor 3. Antimicrobial spectrum: Gram-positive bacterial.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P280-P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Faceshields, Gloves|
|Hazard Codes (Europe)||Xi|
|Risk Statements (Europe)||36-43|
|Safety Statements (Europe)||26-36/37|
Increasing antibiotic resistance and the lack of new drug development have hindered the success of antibiotics in recent years. Staph aureus is susceptible to a number of antibiotics with various mec...
3. Modulation of Chaperone Function and Cochaperone Interaction by Novobiocin in the C-terminal Domain of Hsp90: EVIDENCE THAT COUMARIN ANTIBIOTICS DISRUPT Hsp90 DIMERIZATION. Rudi K. Allan, Danny Mok, et al . J. Biol. Chem. 281, 7161-7171, (2006)
Staphylococcus petrasii sp. nov. including S. petrasii subsp. petrasii subsp. nov. and S. petrasii subsp. croceilyticus subsp. nov., isolated from human clinical specimens and human ear infections. Pantůček R, Švec P, Dajcs JJ, et al. Syst. Appl. Microbiol. 36(2), 90-5, (2013)
KU-32, a novel drug for diabetic neuropathy, is safe for human islets and improves in vitro insulin secretion and viability. Farmer K, Williams SJ, Novikova L, et al. Exp. Diabetes Res. 2012, 671673, (2012)
Aminocoumarins inhibit osteoclast differentiation and bone resorption via downregulation of nuclear factor of activated T cells c1. Zheng T, Noh AL, Park H, et al. Biochem. Pharmacol. 85(3), 417-25, (2013)
Rhomboids of Mycobacteria: characterization using an aarA mutant of Providencia stuartii and gene deletion in Mycobacterium smegmatis. Kateete DP, Katabazi FA, Okeng A, et al. PLoS ONE 7(9), e45741, (2012)
Attenuation of a virulent Aeromonas hydrophila with novobiocin and pathogenic characterization of the novobiocin-resistant strain. Pridgeon JW, Yildirim-Aksoy M, Klesius PH, et al. J. Appl. Microbiol. 113(6), 1319-28, (2012)
C-terminal heat shock protein 90 inhibitor decreases hyperglycemia-induced oxidative stress and improves mitochondrial bioenergetics in sensory neurons. Zhang L, Zhao H, Blagg BS, et al. J. Proteome Res. 11(4), 2581-93, (2012)
A combination of direct viable count and fluorescence in situ hybridization for specific enumeration of viable Lactobacillus delbrueckii subsp.bulgaricus and Streptococcus thermophilus. García-Hernández J, Moreno Y, Amorocho CM, et al. Lett. Appl. Microbiol. 54(3), 247-54, (2012)
Synthesis and structure-activity relationships of novel amino/nitro substituted 3-arylcoumarins as antibacterial agents. Matos MJ, Vazquez-Rodriguez S, Santana L, et al. Molecules 18(2), 1394-404, (2013)
Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells. Giessrigl B, Krieger S, Rosner M, et al. Hum. Mol. Genet. 21(21), 4615-27, (2012)
Potent antiviral activity of topoisomerase I and II inhibitors against Kaposi's sarcoma-associated herpesvirus. González-Molleda L, Wang Y, and Yuan Y Antimicrob. Agents Chemother. 56(2), 893-902, (2012)
Synthesis, antimicrobial activity and molecular modeling study of substituted 5-aryl-pyrimido[5,4-c]quinoline-2,4-diones. Ismail MA, Al-Shihry S, Arafa RK, et al. J. Enzyme Inhib. Med. Chem. 28(3), 530-8, (2013)
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