|Related Categories||Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Merck,|
|color||white to off-white|
|solubility||DMSO: >5 mg/mL|
Nefiracetam (NEF) is a pyrrolidonetype nootropic agent with various pharmacologic as well as cognition enhancing effects. In amygdala-kindled seizures, nefiracetam inhibits both electroencephalographic and behavioral seizures. NEF has a distinct anticonvulsant spectrum.
Nefiracetam attenuates post-ischemic nonconvulsive seizures in rats and protects neuronal cell death induced by veratridine and glutamate. Lu XC, Dave JR, Chen Z, et al. Life Sci. 92(22), 1055-63, (2013)
Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice. Moriguchi S, Han F, Shioda N, et al. J. Neurochem. 110(1), 170-81, (2009)
Nefiracetam and galantamine modulation of excitatory and inhibitory synaptic transmission via stimulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons. Moriguchi S, Zhao X, Marszalec W, et al. Neuroscience 160(2), 484-91, (2009)
CaM kinase II and protein kinase C activations mediate enhancement of long-term potentiation by nefiracetam in the rat hippocampal CA1 region. Moriguchi S, Shioda N, Han F, et al. J. Neurochem. 106(3), 1092-103, (2008)
Nefiracetam potentiates N-methyl-D-aspartate (NMDA) receptor function via protein kinase C activation and reduces magnesium block of NMDA receptor. Moriguchi S, Shioda N, Maejima H, et al. Mol. Pharmacol. 71(2), 580-7, (2007)
[Evaluation methods for the discriminative stimulus and possible mechanisms of discriminative stimulus effects of methamphetamine in the rat]. Mizoguchi H, Noda Y, and Nabeshima T Nippon. Yakurigaku Zasshi. 126(1), 17-23, (2005)
Anticonvulsant and neuroprotective effects of the novel nootropic agent nefiracetam on kainic acid-induced seizures in rats. Kitano Y, Komiyama C, Makino M, et al. Brain Res. 1057(1-2), 168-76, (2005)
Investigation on urinary proteins and renal mRNA expression in canine renal papillary necrosis induced by nefiracetam. Tsuchiya Y, Tominaga Y, Matsubayashi K, et al. Arch. Toxicol. 79(9), 500-7, (2005)
Chronic exposure of rats to cognition enhancing drugs produces a neuroplastic response identical to that obtained by complex environment rearing. Murphy KJ, Foley AG, O'connell AW, et al. Biol. Psychiatry 31(1), 90-100, (2006)
Effects of nefiracetam on the levels of brain-derived neurotrophic factor and synapsin I mRNA and protein in the hippocampus of microsphere-embolized rats. Ando T, Takagi N, Takagi K, et al. Eur. J. Pharmacol. 507(1-3), 49-56, (2005)
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