|Related Categories||Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antifungal, Biochemicals and Reagents,|
Nikkomycin Z is used as a selective competitive inhibitor of chitin synthetase 3 in studies on fungal cell wall development. It is a potential treatment for human Encephalitozoon hellem, a microsporidian species1 and is used to study the changes of chitin and β--glucan under Nikkomycin Z exposure2.
Nikkomycin Z inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine3. Nikkomycin Z has potent antifungal, insecticidal and acaridicial activity.
Certificate of Analysis
|Precautionary statements||P261-P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xi|
|Risk Statements (Europe)||36/37/38|
|Safety Statements (Europe)||26-36|
1. In Vitro Efficacy of Nikkomycin Z against the Human Isolate of the Microsporidian Species Encephalitozoon hellem Elisa Bigliardi, Anna Maria Bernuzzi, et al. Antimicrob. Agents Chemother. 44, 3012-3016, (2000)
2. Reshuffling of Aspergillus fumigatus Cell Wall Components Chitin and β-Glucan under the Influence of Caspofungin or Nikkomycin Z Alone or in Combination Patricia E. B. Verwer, M. L. van Duijn, et al. Antimicrob. Agents Chemother. 56, 1595-1598, (2012)
3. Identification of GIG1, a GlcNAc-Induced Gene in Candida albicans Needed for Normal Sensitivity to the Chitin Synthase Inhibitor Nikkomycin Z Angelo Gunasekera, Francisco J. Alvarez, et al. Eukaryotic Cell 9, 1476-1483, (2010)
Sudoh, M., et al. J. Gen. Microbiol. 141, 2673, (1995)
Novel polyoxins generated by heterologously expressing polyoxin biosynthetic gene cluster in the sanN inactivated mutant of Streptomyces ansochromogenes. Li J, Li L, Feng C, et al. Microb. Cell Fact. 11, 135, (2012)
Effect of nikkomycin Z and 50% human serum on the killing activity of high-concentration caspofungin against Candida species using time-kill methodology. Szilágyi J, Földi R, Bayegan S, et al. J. Chemother. 24(1), 18-25, (2012)
Differential cell wall remodeling of two chitin synthase deletants Δchs3A and Δchs3B in the pathogenic yeast Candida glabrata. Ueno K, Namiki Y, Mitani H, et al. FEMS Yeast Res. 11(5), 398-407, (2011)
Cloning, reassembling and integration of the entire nikkomycin biosynthetic gene cluster into Streptomyces ansochromogenes lead to an improved nikkomycin production. Liao G, Li J, Li L, et al. Microb. Cell Fact. 9, 6, (2010)
SanG, a transcriptional activator, controls nikkomycin biosynthesis through binding to the sanN-sanO intergenic region in Streptomyces ansochromogenes. He X, Li R, Pan Y, et al. Microbiology 156(Pt 3), 828-37, (2010)
Selectively improving nikkomycin Z production by blocking the imidazolone biosynthetic pathway of nikkomycin X and uracil feeding in Streptomyces ansochromogenes. Liao G, Li J, Li L, et al. Microb. Cell Fact. 8, 61, (2009)
Probing the role of active site residues in NikD, an unusual amino acid oxidase that catalyzes an aromatization reaction important in nikkomycin biosynthesis. Kommoju PR, Bruckner RC, Ferreira P, et al. Biochemistry 48(29), 6951-62, (2009)
SabR enhances nikkomycin production via regulating the transcriptional level of sanG, a pathway-specific regulatory gene in Streptomyces ansochromogenes. Pan Y, Wang L, He X, et al. BMC Microbiol. 11, 164, (2011)
Studies on peptidyl nucleoside antibiotics: synthesis and antifungal evaluation of pyranosyl nucleoside analogs of nikkomycin. Stauffer CS, Fothergill AW, Rinaldi MG, et al. Future Med. Chem. 1(2), 379-89, (2009)
The Aspergillus fumigatus P-type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis. Pinchai N, Juvvadi PR, Fortwendel JR, et al. Eukaryotic Cell 9(3), 472-6, (2010)
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