Nikkomycin Z from Streptomyces tendae
≥90% (HPLC)
DOWNLOAD MSDS (PDF)-
CAS Number 59456-70-1
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Empirical Formula (Hill Notation) C20H25N5O10
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Molecular Weight 495.44
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MDL number MFCD00869648
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PubChem Substance ID 24897849
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Popular Documents: Specification Sheet (PDF)
Properties
| Related Categories | Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antifungal, Chemical Structure Class, |
| assay | ≥90% (HPLC) |
| storage temp. | 2-8°C |
Description
Application
Nikkomycin Z is used as a selective competitive inhibitor of chitin synthetase 3 in studies on fungal cell wall development. It is a potential treatment for human Encephalitozoon hellem, a microsporidian species1 and is used to study the changes of chitin and β--glucan under Nikkomycin Z exposure2.
Biochem/physiol Actions
Nikkomycin Z inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine3. Nikkomycin Z has potent antifungal, insecticidal and acaridicial activity.
Price and Availability
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