Pifithrin-μ
≥97% (HPLC), solid
DOWNLOAD MSDS (PDF)Synonym:
2-
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CAS Number 64984-31-2
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Empirical Formula (Hill Notation) C8H7NO2S
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Molecular Weight 181.21
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MDL number MFCD00181531
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PubChem Substance ID 24724568
Properties
| Related Categories | Apoptosis Inhibitors, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, |
| assay | ≥97% (HPLC) |
| form | solid |
| storage condition | desiccated |
| solubility | DMSO: >10 mg/mL |
| H2O: <2 mg/mL | |
| storage temp. | 2-8°C |
Description
Biochem/physiol Actions
Pifithrin-μ is an inhibitor of p53 binding and anti-apoptotic, which directly inhibits p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins. PFTμ rescues cells from lethal γ-irradiation-induced cell death. Because pifithrin-μ shuts down only the p53-mitochondrial pathway without affecting the transcriptional functions of p53, it is superior to pifithrin-α.
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≥97% (HPLC), lyophilized powder
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