Protein Kinase Inhibitor from porcine heart
1-3 inhibitor U/μg protein, lyophilized powder
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MDL number MFCD00132115
Properties
| Related Categories | Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, |
| form | lyophilized powder |
| composition | Protein, ~50% biuret |
| storage temp. | 2-8°C |
Description
Biochem/physiol Actions
These proteins bind to the catalytic subunit of cyclic-AMP dependent protein kinase, displacing the regulatory subunit and inhibiting phosphorylating activity. The cyclic-AMP binding capacity of the regulatory subunit is enhanced. Many other proteins exhibit this enhancement ability, too (Brostrom, C.O. and Kon, C., Anal. Biochem., 58, 459 [1974]).
Packaging
Package size based on protein content.
Preparation Note
Fractionated essentially by procedure of Walsh, D.A., et al., J. Biol. Chem., 246, 1977 (1971).
Unit Definition
One unit will transfer 1.0 picomole (10-12 mol) of phosphate from γ-32P-ATP to hydrolyzed and partially dephosphorylated casein (Product No. C 4765) per min at pH 6.5 at 30 °C.
Physical form
Supplied as lyophilized powder containing 30% glycerophosphate and 20% EDTA.
Price and Availability
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