|Related Categories||Bioactive Small Molecules, Cell Biology, Cell Lysis and Protein Extraction, Core Bioreagents, Life Science Reagents for Protein Expression and Purification,|
|shipped in||dry ice|
After 48 hours in medium, add fresh inhibitors in fresh medium.
After 48 hours exposure, the product is non-toxic to adherent cell lines A431, CHO, COS, HepG2 and HeLa; and to Jurkat and HL-60 cell lines grown in suspension.
Mixture of protease inhibitors with broad specificity for the inhibtion of serine, cysteine, aspartic and aminopeptidases. Contains aprotinin, bestatin, leupeptin, E-64, and pepstatin A. Contains no metal chelators
Use at a dilution of 1:200 or more in tissue culture media to prevent proteolytic degradation of secreted proteins.
Inhibits serine, cysteine, aspartic proteases, and aminopeptidases
Solution in DMSO (D 2650, Hybri-Max).
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ABC transporter A3 facilitates lysosomal sequestration of imatinib and modulates susceptibility of chronic myeloid leukemia cell lines to this drug. Bjoern Chapuy et al Haematologica 94, 1528-36, (2009)
Kaposi sarcoma-associated herpes virus (KSHV) G protein-coupled receptor (vGPCR) activates the ORF50 lytic switch promoter: a potential positive feedback loop for sustained ORF50 gene expression. Virginie Bottero et al Virology 392, 34-51, (2009)
Ingestion of 10 grams of whey protein prior to a single bout of resistance exercise does not augment Akt/mTOR pathway signaling compared to carbohydrate. Matthew B Cooke et al J. Int. Soc. Sports Nutr. 8, 18, (2011)
Integrin alpha1beta1 regulates matrix metalloproteinases via P38 mitogen-activated protein kinase in mesangial cells: implications for Alport syndrome. Cosgrove D Am. J. Pathol. 172(3), 761-73, (2008)
Modulation of interleukin-1β-induced inflammatory responses by a synthetic cationic innate defence regulator peptide, IDR-1002, in synovial fibroblasts. Turner-Brannen E Arthritis. Res. Ther. 13(4), R129, (2011)
Mechanical wounding induces a nitrosative stress by down-regulation of GSNO reductase and an increase in S-nitrosothiols in sunflower (Helianthus annuus) seedlings. Chaki M J. Exp. Bot. 62(6), 1803-13, (2011)
Effects of 28 days of resistance exercise while consuming commercially available pre- and post-workout supplements, NO-Shotgun® and NO-Synthesize® on body composition, muscle strength and mass, markers of protein synthesis, and clinical safety markers in males. Spillane M Nutr. Metab. 8, 78, (2011)
Arabidopsis Tic40 expression in tobacco chloroplasts results in massive proliferation of the inner envelope membrane and upregulation of associated proteins. Singh ND Plant Cell 20(12), 3405-17, (2008)
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|P8340||Protease Inhibitor Cocktail, for use with mammalian cell and tissue extracts, DMSO solution|
|P8215||Protease Inhibitor Cocktail, for use with fungal and yeast extracts, DMSO solution|
|P2714||Protease Inhibitor Cocktail, for general use, lyophilized powder|
|P8849||Protease Inhibitor Cocktail, for use in purification of Histidine-tagged proteins, DMSO solution|
|P9599||Protease Inhibitor Cocktail, for plant cell and tissue extracts, DMSO solution|
|S8820||SIGMAFAST™ Protease Inhibitor Tablets, For General Use|
|S8830||SIGMAFAST™ Protease Inhibitor Cocktail Tablets, EDTA-Free, for use in purification of Histidine-tagged proteins|
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