Polydeoxyguanylic acid · Polydeoxycytidylic acid sodium salt double-stranded homopolymer

Properties

Related Categories	Biochemicals and Reagents, Biomaterials, Materials Science, Nucleosides, Nucleotides, Oligonucleotides, Oligonucleotide Polymers and Copolymers, Synthetic Oligonucleotides and Related Reagents More...
storage temp.	−20°C

Description

Other Notes

High molecular weight double-stranded homopolymer

Reconstitution

Polymers composed of dG and dC can be difficult to dissolve. The recommended dissolution method for poly(dG) • poly(dC) is to suspend the polymer in a minimum of 15 μl per unit in water or buffer and heat to 50-55 °C for 30 minutes with occasional mixing by inversion.

Unit Definition

One unit will yield an A₂₆₀ of 1.0 in 1.0 ml of 20 mM sodium phosphate/100 mM NaCl, pH 7.0 (1 cm light path).

Application

Polydeoxyguanylic acid • Polydeoxycytidylic acid (Poly(dG) • Poly(dC)) is a high molecular weight double-stranded homopolymer DNA model compound used for conformational studies of DNA structure dynamics and drug and small molecule interactions.

Price and Availability

Related Papers

Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC). Behe M, Felsenfeld G. Proc. Natl. Acad. Sci. U. S. A. 78, 1619-1623, (1981)

Documents

Certificate of Analysis

Certificate of Origin

Safety Information

Personal Protective Equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany	3

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Papers

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Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC). Behe M, Felsenfeld G. Proc. Natl. Acad. Sci. U. S. A. 78, 1619-1623, (1981)

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Acid titrations of poly(dG-dC).poly(dG-dC) in aqueous solution and in a w/o microemulsion. Airoldi M, Boicelli CA, Gennaro G, et al. J. Biomol. Struct. Dyn. 23, 465-478, (2006)

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Luminescent Ir(III) Complex Exclusively Made of Polypyridine Ligands Capable of Intercalating into Calf-Thymus DNA. Campagna S, Cavazzini M, Cusumano M, et al. Inorg. Chem. 50, 10667-10672, (2011)

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Studies of the fluorescence light-up effect of amino-substituted benzo[b]quinolizinium derivatives in the presence of biomacromolecules. Faulhaber K, Granzhan A, Ihmels H, et al. Photochem. Photobiol. 10, 1535-1545, (2011)

Effect of the Alkaline Cations on the Stability of the Model PolynucleotidePoly(dG-dC)•Poly(dG-dC). Airoldi M, Gennaro G, Giomini M, et al. J. Biomol. Struct. Dyn. 29, 585-594, (2011)

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