Podophyllotoxin

Papers

Podophyllotoxin and nocodazole counter the effect of IKP104 on tubulin decay. Prasad, V., et al. J. Protein Chem. 17, 663, (1998)

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Podophyllotoxins: current status and recent developments. Damayanthi, Y. and Lown, J.W. Curr. Med. Chem. 5, 205, (1998)

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CHMIS-C: a comprehensive herbal medicine information system for cancer. Xueliang Fang et al J. Med. Chem. 48, 1481-8, (2005)

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Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate. Brittany Lee et al J. Med. Chem. 48, 7400-10, (2005)

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Conformationally restricted analogs of Combretastatin A-4 derived from SU5416. Pui-Kai Li et al Bioorg. Med. Chem. Lett. 15, 5382-5, (2005)

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Isoneocryptolepine, a synthetic indoloquinoline alkaloid, as an antiplasmodial lead compound. Sabine Van Miert et al J. Nat. Prod. 68, 674-7, (2005)

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Benzoylphenylurea sulfur analogues with potent antitumor activity. Gurulingappa Hallur et al J. Med. Chem. 49, 2357-60, (2006)

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Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents. Romeo Romagnoli et al J. Med. Chem. 49, 3906-15, (2006)

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Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. Corinne Nguyen et al J. Med. Chem. 49, 4183-95, (2006)

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[4-(imidazol-1-yl)thiazol-2-yl]phenylamines. A novel class of highly potent colchicine site binding tubulin inhibitors: synthesis and cytotoxic activity on selected human cancer cell lines. Siavosh Mahboobi et al J. Med. Chem. 49, 5769-76, (2006)

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Evaluation of azasterols as anti-parasitics. Ludovic Gros et al J. Med. Chem. 49, 6094-103, (2006)

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Synthesis and structure-activity relationships of carbazole sulfonamides as a novel class of antimitotic agents against solid tumors. Laixing Hu et al J. Med. Chem. 49, 6273-82, (2006)

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9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization. Anne Zuse et al J. Med. Chem. 49, 7816-25, (2006)

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Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents. Julieta Coro et al Bioorg. Med. Chem. Lett. 16, 1312-5, (2006)

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Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase. Orla K Mc Carthy et al Bioorg. Med. Chem. Lett. 16, 3809-12, (2006)

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Endophyte fungal isolates from Podophyllum peltatum produce podophyllotoxin. Amy L Eyberger et al J. Nat. Prod. 69, 1121-4, (2006)

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Isoflavonoids and other compounds from Psorothamnus arborescens with antiprotozoal activities. Manar M Salem et al J. Nat. Prod. 69, 43-9, (2006)

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Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles. Donald A Patrick et al J. Med. Chem. 50, 2468-85, (2007)

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Discovery and investigation of antiproliferative and apoptosis-inducing properties of new heterocyclic podophyllotoxin analogues accessible by a one-step multicomponent synthesis. Igor V Magedov et al J. Med. Chem. 50, 5183-92, (2007)

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Synthesis and in vitro antiprotozoal activity of bisbenzofuran cations. Svetlana M Bakunova et al J. Med. Chem. 50, 5807-23, (2007)

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Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives. Sabine Kuettel et al J. Med. Chem. 50, 5833-9, (2007)

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Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization. Anne Zuse et al J. Med. Chem. 50, 6059-66, (2007)

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Synthesis and pharmacological evaluation of fluorescent and photoactivatable analogues of antiplasmodial naphthylisoquinolines. Gerhard Bringmann et al J. Med. Chem. 50, 6104-15, (2007)

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Novel pyridinyl and pyrimidinylcarbazole sulfonamides as antiproliferative agents. Laixing Hu et al Bioorg. Med. Chem. Lett. 17, 1193-6, (2007)

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Structural simplification of bioactive natural products with multicomponent synthesis: dihydropyridopyrazole analogues of podophyllotoxin. Igor V Magedov et al Bioorg. Med. Chem. Lett. 17, 1381-5, (2007)

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Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives. Shi-Wu Chen et al Bioorg. Med. Chem. Lett. 17, 2091-5, (2007)

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Novel potent antimitotic heterocyclic ketones: synthesis, antiproliferative activity, and structure-activity relationships. Laixing Hu et al Bioorg. Med. Chem. Lett. 17, 3613-7, (2007)

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3-(2'-Bromopropionylamino)-benzamides as novel S-phase arrest agents. Laixing Hu et al Bioorg. Med. Chem. Lett. 17, 6847-52, (2007)

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Synthesis and cytotoxic evaluation of C-9 oxidized podophyllotoxin derivatives. Ma Angeles Castro et al Bioorg. Med. Chem. 15, 1670-8, (2007)

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Anti-malarial activity of N6-modified purine analogues. Kathleen Too et al Bioorg. Med. Chem. 15, 5551-62, (2007)

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Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents. Tesmol G George et al Bioorg. Med. Chem. 15, 6071-9, (2007)

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Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry. Daniela Imperio et al Bioorg. Med. Chem. 15, 6748-57, (2007)

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Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli. Deniz Tasdemir et al Bioorg. Med. Chem. 15, 6834-45, (2007)

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Quinuclidine derivatives as potential antiparasitics. Simon B Cammerer et al Antimicrob. Agents Chemother. 51, 4049-61, (2007)

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Antiprotozoal polyacetylenes from the Tanzanian medicinal plant Cussonia zimmermannii. Martin Senn et al J. Nat. Prod. 70, 1565-9, (2007)

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Lignans from Dysosma versipellis with inhibitory effects on prostate cancer cell lines. Ren-Wang Jiang et al J. Nat. Prod. 70, 283-6, (2007)

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Limonoid orthoacetates and antiprotozoal compounds from the roots of Pseudocedrela kotschyi. Anne-Emmanuelle Hay et al J. Nat. Prod. 70, 9-13, (2007)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum. Wolfgang Friebolin et al J. Med. Chem. 51, 1260-77, (2008)

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Cytotoxic simplified tubulysin analogues. Bhooma Raghavan et al J. Med. Chem. 51, 1530-3, (2008)

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Structural simplification of bioactive natural products with multicomponent synthesis. 2. antiproliferative and antitubulin activities of pyrano[3,2-c]pyridones and pyrano[3,2-c]quinolones. Igor V Magedov et al J. Med. Chem. 51, 2561-70, (2008)

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Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive 3,7-bis(dialkylamino)phenoxazin-5-ium derivatives. Jian-Feng Ge et al J. Med. Chem. 51, 3654-8, (2008)

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Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans. Stanislav A Bakunov et al J. Med. Chem. 51, 6927-44, (2008)

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Novel three-component synthesis and antiproliferative properties of diversely functionalized pyrrolines. Igor V Magedov et al Bioorg. Med. Chem. Lett. 18, 1392-6, (2008)

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Gallic acid-based indanone derivatives as anticancer agents. Hari Om Saxena et al Bioorg. Med. Chem. Lett. 18, 3914-8, (2008)

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Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro. Takeki Saitoh et al Bioorg. Med. Chem. 16, 5815-25, (2008)

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Inhibitors of tubulin polymerization: synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III. Daniele Passarella et al Bioorg. Med. Chem. 16, 6269-85, (2008)

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Structure-activity relationship studies on a novel class of antiproliferative agents derived from Lavendustin A. Part I: Ring A modifications. Peter Nussbaumer et al Bioorg. Med. Chem. 16, 7552-60, (2008)

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Synthesis and structure-activity relationship of 3-phenylquinoxaline 1,4-di-N-oxide derivatives as antimalarial agents. Esther Vicente et al Eur. J. Med. Chem. 43, 1903-10, (2008)

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Studies on novel 4beta-[(4-substituted)-1,2,3-triazol-1-yl] podophyllotoxins as potential anticancer agents. Bilal A Bhat et al Eur. J. Med. Chem. 43, 2067-72, (2008)

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Synthesis and antiprotozoal activities of simplified analogs of naphthylisoquinoline alkaloids. Gerhard Bringmann et al Eur. J. Med. Chem. 43, 32-42, (2008)

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Antiprotozoal activities of heterocyclic-substituted xanthones from the marine-derived fungus Chaetomium sp. Alexander Pontius et al J. Nat. Prod. 71, 1579-84, (2008)

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10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. Helge Prinz et al J. Med. Chem. 52, 1284-94, (2009)

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Structure-activity study of pentamidine analogues as antiprotozoal agents. Svetlana M Bakunova et al J. Med. Chem. 52, 2016-35, (2009)

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Synthesis and antiprotozoal activity of pyridyl analogues of pentamidine. Svetlana M Bakunova et al J. Med. Chem. 52, 4657-67, (2009)

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Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase. Andrea Cavalli et al Bioorg. Med. Chem. Lett. 19, 3031-5, (2009)

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Synthesis and biological evaluation of novel conjugates of podophyllotoxin and 5-FU as antineoplastic agents. Shi-Wu Chen et al Bioorg. Med. Chem. 17, 3111-7, (2009)

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Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues. Van Baelen, G., et al. Bioorg. Med. Chem. 17, 7209-7217, (2009)

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Redox-active dinitrodiphenylthioethers against Leishmania: synthesis, structure-activity relationships and mechanism of action studies. Dawn A Delfín et al Bioorg. Med. Chem. 17, 820-9, (2009)

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Synthesis and antiparasitic and antifungal evaluation of 2'-arylsubstituted-1H,1'H-[2,5']bisbenzimidazolyl-5-carboxamidines. Mehmet Alp et al Eur. J. Med. Chem. 44, 2002-8, (2009)

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Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes. Donald A Patrick et al Eur. J. Med. Chem. 44, 3543-51, (2009)

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Antiplasmodial and antitrypanosomal activities of aminobicyclo[2.2.2]octyl omega-aminoalkanoates. Christian Schlapper et al Eur. J. Med. Chem. 44, 736-44, (2009)

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GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. Grushenka H I Wolfgang et al Antimicrob. Agents Chemother. 53, 2777-84, (2009)

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Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity. Georgina A Holloway et al Antimicrob. Agents Chemother. 53, 2824-33, (2009)

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Compounds structurally related to ellagic acid show improved antiplasmodial activity. Nicole Sturm et al Antimicrob. Agents Chemother. 53, 622-30, (2009)

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Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity. Simon M N Efange et al J. Nat. Prod. 72, 280-3, (2009)

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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Jing Yuan et al Nat. Chem. Biol. 5, 765-71, (2009)

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Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles. Stanislav A Bakunov et al J. Med. Chem. 53, 254-72, (2010)

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Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives. Jean Fotie et al J. Med. Chem. 53, 966-82, (2010)

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Synthesis and biological evaluation of new podophyllic aldehyde derivatives with cytotoxic and apoptosis-inducing activities. Ma Angeles Castro et al J. Med. Chem. 53, 983-93, (2010)

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Podophyllotoxin analogues active versus Trypanosoma brucei. Md Jashim Uddin et al Bioorg. Med. Chem. Lett. 20, 1787-91, (2010)

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Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi. G A Holloway et al Bioorg. Med. Chem. Lett. 20, 1816-8, (2010)

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Synthesis, stereoelectronic characterization and antiparasitic activity of new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinolines. Romina J Pagliero et al Bioorg. Med. Chem. 18, 142-50, (2010)

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2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Deniz Tasdemir et al Bioorg. Med. Chem. 18, 7475-85, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays. Alex S Kiselyov et al Eur. J. Med. Chem. 45, 1683-97, (2010)

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Synthesis and biological evaluation of novel thiocolchicine-podophyllotoxin conjugates. Daniele Passarella et al Eur. J. Med. Chem. 45, 219-26, (2010)

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Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives. Georg Surkau et al Eur. J. Med. Chem. 45, 3354-64, (2010)

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Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety. Holger C Nickel et al Eur. J. Med. Chem. 45, 3420-38, (2010)

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Synthesis and cytotoxicity evaluation of novel 1,4-disubstituted 1,2,3-triazoles via CuI catalysed 1,3-dipolar cycloaddition. Jyothi Vantikommu et al Eur. J. Med. Chem. 45, 5044-50, (2010)

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QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids. Gerhard Bringmann et al Eur. J. Med. Chem. 45, 5370-83, (2010)

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Antiprotozoal steroidal saponins from the marine sponge Pandaros acanthifolium. Erik L Regalado et al J. Nat. Prod. 73, 1404-10, (2010)

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Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. Kuo-Hsiung Lee et al J. Nat. Prod. 73, 500-16, (2010)

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Jacaranone-derived glucosidic esters from Jacaranda glabra and their activity against Plasmodium falciparum. M Salomé Gachet et al J. Nat. Prod. 73, 553-6, (2010)

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Anticancer Properties of an Important Drug Lead Podophyllotoxin Can Be Efficiently Mimicked by Diverse Heterocyclic Scaffolds Accessible via One-Step Synthesis Magedov, I. V.; et al. J. Med. Chem. 54, 4234, (2011)

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N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. Helge Prinz et al J. Med. Chem. 54, 4247-63, (2011)

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Antimalarial Pyrido[1,2-a]benzimidazoles A. J. Ndakala, et al., J. Med. Chem. 54, 4581-4589, (2011)

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Polyalkoxybenzenes from plants. 5. Parsley seed extract in synthesis of azapodophyllotoxins featuring strong tubulin destabilizing activity in the sea urchin embryo and cell culture assays. Marina N Semenova et al J. Med. Chem. 54, 7138-49, (2011)

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An efficient one-pot synthesis of benzothiazolo-4?-anilino-podophyllotoxin congeners: DNA topoisomerase-II inhibition and anticancer activity. Ahmed Kamal et al Bioorg. Med. Chem. Lett. 21, 350-3, (2011)

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Three new cytotoxic aryltetralin lignans from Sinopodophyllum emodi. Yan-Jun Sun et al Bioorg. Med. Chem. Lett. 21, 3794-7, (2011)

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Antiplasmodial and cytotoxicity evaluation of 3-functionalized 2-azetidinone derivatives. Pardeep Singh et al Bioorg. Med. Chem. Lett. 21, 4561-3, (2011)

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Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives. Xue-Liang Shi et al Bioorg. Med. Chem. Lett. 21, 5804-7, (2011)

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Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis). Fadoua Bouchikhi et al Bioorg. Med. Chem. Lett. 21, 6319-21, (2011)

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Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents Kamal, A.; et al. Bioorg. Med. Chem. 19, 2349, (2011)

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?-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. Beatriz Baragaña et al Bioorg. Med. Chem. 19, 2378-91, (2011)

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Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization. Helge Prinz et al Bioorg. Med. Chem. 19, 4183-91, (2011)

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Synthesis and biological evaluation of 4?-acrylamidopodophyllotoxin congeners as DNA damaging agents. Ahmed Kamal et al Bioorg. Med. Chem. 19, 4589-600, (2011)

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Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation. Carolyn S Reid et al Bioorg. Med. Chem. 19, 513-23, (2011)

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Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents. Annie Mayence et al Bioorg. Med. Chem. 19, 7493-500, (2011)

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Synthesis of 4?-triazole-podophyllotoxin derivatives by azide-alkyne cycloaddition and biological evaluation as potential antitumor agents. Hong Chen et al Eur. J. Med. Chem. 46, 4709-14, (2011)

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Antimalarial ?-carbolines from the New Zealand ascidian Pseudodistoma opacum. Susanna T S Chan et al J. Nat. Prod. 74, 1972-9, (2011)

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Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense. M Salomé Gachet et al J. Nat. Prod. 74, 559-66, (2011)

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Marinoquinolines A-F, pyrroloquinolines from Ohtaekwangia kribbensis (Bacteroidetes). Patrick W Okanya et al J. Nat. Prod. 74, 603-8, (2011)

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Didemnidines A and B, indole spermidine alkaloids from the New Zealand ascidian Didemnum sp. Rhys Finlayson et al J. Nat. Prod. 74, 888-92, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Synthesis, characterization and in vitro biological evaluation of some novel diarylsulfonylureas as potential cytotoxic and antimicrobial agents. Vasudeva Rao Avupati et al Bioorg. Med. Chem. Lett. 22, 1031-5, (2012)

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Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers. Stephen T McCracken et al Bioorg. Med. Chem. 20, 1482-93, (2012)

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Synthesis and anticancer activity of 4?-alkylamidochalcone and 4?-cinnamido linked podophyllotoxins as apoptotic inducing agents. Ahmed Kamal et al Eur. J. Med. Chem. 47, 530-45, (2012)

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Synthesis and anti-protozoal activity of novel dihydropyrrolo[3,4-d][1,2,3]triazoles. Ya?ar Dürüst et al Eur. J. Med. Chem. 48, 296-304, (2012)

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Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7. Wen-Ting Huang et al Eur. J. Med. Chem. 49C, 48-54, (2012)

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Merck 14,7546

Beil. 19,V,10,666

Aldrich MSDS 1, 1507:A / Corp MSDS 1 (2), 2857:B / FT-IR 2 (2), 2900:A / FT-IR 1 (2), 320:A / FT-NMR 1 (2), 1304:A / IR-Spectra (3), 1042:E / IR-Spectra (2), 911:G / RegBook 1 (2), 1937:I / Sigma FT-IR 1 (1), 572:D / Structure Index 1, 311:B:7