p53 human
recombinant, expressed in baculovirus infected Sf21 cells
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Properties
| Related Categories | Apoptosis and Cell Cycle, Cell Biology, Cell Cycle Proteins and Antibodies, Cell Signaling and Neuroscience, Cyclins and Nuclear Proteins, |
| recombinant | expressed in baculovirus infected Sf21 cells |
| assay | ≥90% (SDS-PAGE) |
| form | aqueous solution |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... TP53(7157) |
Description
Application
Useful for the study of postranslational modification of p53, or protein-protein interaction studies.
Physical form
Supplied as a solution in 20 mM Tris-HCl, pH 8.0, 20% glycerol, 100 mM KCl, 0.2 mM EDTA, and 1 mM DTT.
Biochem/physiol Actions
In addition, p53 was recently shown to induce differentiation of human embryonic stem cells. The effect is dependent on the DNA binding activity of p53. 1
p53 gene is highly conserved and expressed in normal tissues. It is the most commonly mutated gene in human cancer and more then 500 gene mutations have been described in various types of malignancies, hematologic as well as solid tumors. Intact p53 function is essential for the maintenance of the non-tumorogenic phenotype of cells. Thus, p53 plays a vital role in suppressing the development of cancer.
Physical properties
Histidine-tagged, full length human p53
Price and Availability
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