CP-471474
≥98% (HPLC)
DOWNLOAD MSDS (PDF)Synonym:
2-
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CAS Number 210755-45-6
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Empirical Formula (Hill Notation) C16H17FN2O5S
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Molecular Weight 368.38
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MDL number MFCD16618408
Properties
| Related Categories | Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, CI-CY, Cell Biology, Cell Signaling and Neuroscience, |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to off-white |
| solubility | DMSO: ≥20 mg/mL |
| storage temp. | room temp |
Description
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
CP-471474 is a broad spectrum inhibitor of matrix metalloproteinases. CP-471474 has a low nM IC50 efficacy for MMP-2, MMP-3, MMP-9, and MMP-13. CP-471474 has low potency against MMP-1 (IC50 > 1 uM). CP-471474 prevents left ventricular remodeling after experimental myocardial infarction in mice. CP-471474 also inhibits cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models.
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