|Related Categories||Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics,|
|storage condition||protect from light|
|solubility||DMSO: >5 mg/mL|
|shipped in||wet ice|
Rifabutin is an antibiotic; antitumor. Rifabutin interferes with HSP-90 molecular chaperone, enhances ubiquitination and protein degradation, and inactivates bacterial RNA polymerase.
Safety, tolerability, and pharmacokinetics of the HIV integrase inhibitor dolutegravir given twice daily with rifampin or once daily with rifabutin: results of a phase 1 study among healthy subjects. Dooley KE, Sayre P, Borland J, et al. J. Acquir. Immune Defic. Syndr. 62(1), 21-7, (2013)
Interplay of mycolic acids, antimycobacterial compounds and pulmonary surfactant membrane: a biophysical approach to disease. Pinheiro M, Giner-Casares JJ, Lúcio M, et al. Biochim. Biophys. Acta 1828(2), 896-905, (2013)
Mycobacterium kansasii pericarditis in a kidney transplant recipient: a case report and comprehensive review of the literature. Cho JH, Yu CH, Jin MK, et al. Transpl. Infect. Dis. 14(5), E50-5, (2012)
Effect of rifampin and rifabutin on the pharmacokinetics of lersivirine and effect of lersivirine on the pharmacokinetics of rifabutin and 25-O-desacetyl-rifabutin in healthy subjects. Vourvahis M, Davis J, Wang R, et al. Antimicrob. Agents Chemother. 56(8), 4303-9, (2012)
Partial biodistribution and pharmacokinetics of isoniazid and rifabutin following pulmonary delivery of inhalable microparticles to rhesus macaques. Kumar Verma R, Mukker JK, Singh RS, et al. Mol. Pharm. 9(4), 1011-6, (2012)
[Efficacy and tolerance of rezonizate in complex with fluoroquinolones or mycobutin on a model of experimental murine tuberculosis]. Sokolova GB, Maliev BM, Mozhokina GN, et al. Antibiot. Khimioter. 56(7-8), 22-6, (2011)
Lopinavir pharmacokinetic profiles in HIV-infected patients during rifabutin-based anti-mycobacterial therapy. Matteelli A, Villani P, Carvalho AC, et al. J. Antimicrob. Chemother. 67(10), 2470-3, (2012)
Fourth-line rescue therapy with rifabutin in patients with three Helicobacter pylori eradication failures. Gisbert JP, Castro-Fernandez M, Perez-Aisa A, et al. Aliment. Pharmacol. Ther. 35(8), 941-7, (2012)
HLA-DRB1*1501 and VDR polymorphisms and survival of Mycobacterium tuberculosis in human macrophages exposed to inhalable microparticles. Singh AK, Abhimanyu, Yadav AB, et al. Pharmacogenomics 14(5), 531-40, (2013)
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