Synonym: Ristocetin sulfate salt
|Related Categories||Antibiotics, Antibiotics A to Z, Antibiotics N-S, Biochemicals and Reagents, Blood,|
|assay||≥90% ristocetin A basis (balance primarily Ristocetin B)|
Ristocetin activates platelets. Ristocetin-induced platelet agglutination (RIPA) is decreased in patients undergoing chronic hemodialysis. Together with increased plasma glycocalicin levels (a product of enzymatic cleavage of GPIb), RIPA may contribute to diminished platelet adhesion to vascular subendothelium and increased bleeding associated with uremia. Addition of ristocetin and vWf caused specific agglutination of rGPIbα-liposomes suporting the potential use of rGPIbα-liposomes to enhance platelet function in vivo and support hemostasis in thrombocytopenic individuals.
Glycopeptide antibiotic complex
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potency: ≥900 μg per mg (as vancomycin base)
Increasing antibiotic resistance and the lack of new drug development have hindered the success of antibiotics in recent years. Staph aureus is susceptible to a number of antibiotics with various mec...
Jordan, D.C., D. Gottlieb and P. Shaw,, ed. Antibiotics New York , (1967) 1, 84
Characterization of liposomes carrying von Willebrand factor-binding domain of platelet glycoprotein Ibα: a potential substitute for platelet transfusion. Kitaguchi, T., et al. Biochem. Biophys. Res. Commun. 261, 784-789, (1999)
Ristocetin- and thrombin-induced platelet aggregation at physiological shear rates: differential roles for GPIb and GPIIb-IIIa receptor. Kasirer-Friede, A, Frojmovic M.M . Thromb. Haemost. 80, 428-436, (1998)
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