Ristomycin monosulfate
≥90% ristocetin A basis (balance primarily Ristocetin B)
DOWNLOAD MSDS (PDF)Synonym: Ristocetin sulfate salt
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CAS Number 11140-99-1
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Empirical Formula (Hill Notation) C95H110N8O44 · H2SO4
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Molecular Weight 2166.00
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MDL number MFCD00076121
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PubChem Substance ID 24899399
Properties
| Related Categories | Antibiotics, Antibiotics A to Z, Antibiotics N-S, Biochemicals and Reagents, Blood, |
| assay | ≥90% ristocetin A basis (balance primarily Ristocetin B) |
| storage temp. | 2-8°C |
Description
Biochem/physiol Actions
Ristocetin activates platelets. Ristocetin-induced platelet agglutination (RIPA) is decreased in patients undergoing chronic hemodialysis. Together with increased plasma glycocalicin levels (a product of enzymatic cleavage of GPIb), RIPA may contribute to diminished platelet adhesion to vascular subendothelium and increased bleeding associated with uremia. Addition of ristocetin and vWf caused specific agglutination of rGPIbα-liposomes suporting the potential use of rGPIbα-liposomes to enhance platelet function in vivo and support hemostasis in thrombocytopenic individuals.
Other Notes
Glycopeptide antibiotic complex
Price and Availability
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