Stromal Cell-Derived Factor 1α/pre-B Cell Growth Stimulating Factor human >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, cell culture tested

Properties

Related Categories	Cell Biology, Cell Signaling and Neuroscience, Chemokines, Cytokines, Cytokines and Growth Factors, Cytokines, Growth Factors and Chemokines for Stem Cell Differentiation, Cytokines, Growth Factors and Hormones, Cytokines, Growth Factors, Chemokines for Stem Cell Biology, Cytokines, Growth Factors, and Chemokines for Stem Cell Expansion, General Stem Cell Biology, Growth Factors, Hematopoietic Stem Cell Biology, Hematopoietic Stem Cell Cytokine and Growth Factors, Mesenchymal Stem Cell Biology, Mesenchymal Stem Cell Biology Growth Factors, Stem Cell Biology, Stem Cell Differentiation, Stem Cell Expansion, Stromal Cell-Derived Factor-1 More...
recombinant	expressed in E. coli
assay	>97% (SDS-PAGE)
form	lyophilized powder
mol wt	predicted mol wt ~8 kDa
impurities	endotoxin, tested
suitability	cell culture tested
storage temp.	−20°C
Gene Information	human ... CXCL12(6387)

Show More (9)

Description

Analysis Note

The biological activity can be measured by its ability to chemoattract 5-10 day cultured human T lymphocytes or chemoattract BaF/3 human CXCR4 cells.

Specificity

Mature human SDF-1α shares 100% amino acid sequence homology with rhesus macaque and feline SDF-1α.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoracetic acid containing 0.5 mg bovine serum albumin.

Biochem/physiol Actions

SDF-1α/PBSF, a member of the α (CXC) chemokine family, is a chemoattractant for T lymphocytes and monocytes, but not neutrophils. SDF-1α/PBSF is highly conserved between species, with only one amino acid substitution between the human and mouse proteins. SDF-1α and SDF-1β are encoded by a single gene and arise by alternative splicing. The two proteins are identical except for the four amino acid residues that are present in the C-terminal of SDF-1β and absent from SDF-1α.. SDF-1/PBSF is a ligand for CXCR4 receptor that functions as a coreceptor for lymphocyte-tropic HIV-1 strains. SDF-1/PBSF is a powerful inhibitor of infection by lymphocyte-tropic HIV-1 strains.