|Related Categories||Cell Biology, Cell Signaling and Neuroscience, Chemokines, Cytokines, Cytokines and Growth Factors,|
|recombinant||expressed in E. coli|
|mol wt||predicted mol wt ~8 kDa|
|suitability||cell culture tested|
|Gene Information||human ... CXCL12(6387)|
The biological activity can be measured by its ability to chemoattract 5-10 day cultured human T lymphocytes or chemoattract BaF/3 human CXCR4 cells.
Mature human SDF-1α shares 100% amino acid sequence homology with rhesus macaque and feline SDF-1α.
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoracetic acid containing 0.5 mg bovine serum albumin.
SDF-1α/PBSF, a member of the α (CXC) chemokine family, is a chemoattractant for T lymphocytes and monocytes, but not neutrophils. SDF-1α/PBSF is highly conserved between species, with only one amino acid substitution between the human and mouse proteins. SDF-1α and SDF-1β are encoded by a single gene and arise by alternative splicing. The two proteins are identical except for the four amino acid residues that are present in the C-terminal of SDF-1β and absent from SDF-1α.. SDF-1/PBSF is a ligand for CXCR4 receptor that functions as a coreceptor for lymphocyte-tropic HIV-1 strains. SDF-1/PBSF is a powerful inhibitor of infection by lymphocyte-tropic HIV-1 strains.
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recombinant, expressed in E. coli, ≥99% (SDS-PAGE), ≥99% (HPLC)
SDF-1α, recombinant, expressed in E. coli, powder, cell culture tested
Chemokines are a family of low molecular weight secreted proteins that act as leukocyte specific chemoattractants, although they may have additional immunological and non-immunological activities. Th...
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