|Related Categories||Cell Biology, Cell Signaling and Neuroscience, Chemokines, Cytokines, Cytokines and Growth Factors,|
|recombinant||expressed in E. coli|
|mol wt||predicted mol wt ~8 kDa|
|suitability||cell culture tested|
|Gene Information||human ... CXCL12(6387)|
The biological activity can be measured by its ability to chemoattract 5-10 day cultured human T lymphocytes or chemoattract BaF/3 human CXCR4 cells.
Mature human SDF-1α shares 100% amino acid sequence homology with rhesus macaque and feline SDF-1α.
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoracetic acid containing 0.5 mg bovine serum albumin.
SDF-1α/PBSF, a member of the α (CXC) chemokine family, is a chemoattractant for T lymphocytes and monocytes, but not neutrophils. SDF-1α/PBSF is highly conserved between species, with only one amino acid substitution between the human and mouse proteins. SDF-1α and SDF-1β are encoded by a single gene and arise by alternative splicing. The two proteins are identical except for the four amino acid residues that are present in the C-terminal of SDF-1β and absent from SDF-1α.. SDF-1/PBSF is a ligand for CXCR4 receptor that functions as a coreceptor for lymphocyte-tropic HIV-1 strains. SDF-1/PBSF is a powerful inhibitor of infection by lymphocyte-tropic HIV-1 strains.
Customers Also Viewed
≥97% (NMR), solid
≥97% (HPLC), powder
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested
recombinant, expressed in E. coli, ≥99% (SDS-PAGE), ≥99% (HPLC)
recombinant, expressed in E. coli, powder, cell culture tested
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?