|Related Categories||Antagonist, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Peptides and Proteins,|
human ... TAC1(6863), TACR1(6869)|
mouse ... TAC1(21333), TACR1(21336)
rat ... TAC1(24806), TACR1(24807)
Potent substance P antagonist with weak histamine-releasing action
Effects of neurokinin-1 and 3-receptor antagonists on the defensive behavior induced by electrical stimulation of the dorsal periaqueductal gray. Broiz AC, Bassi GS, De Souza Silva MA, et al. Neuroscience 201, 134-45, (2012)
The neuropeptide substance P mediates adventitial mast cell activation and induces intraplaque hemorrhage in advanced atherosclerosis. Bot I, de Jager SC, Bot M, et al. Circ. Res. 106(1), 89-92, (2010)
Elevated glucose and fatty acid levels impair substance P-induced dermal microvascular endothelial cell migration and proliferation in an agarose gel model system. Wang Q, Muffley LA, Hall K, et al. Shock 32(5), 491-7, (2009)
Substance P promotes susceptibility to Pseudomonas aeruginosa keratitis in resistant mice: anti-inflammatory mediators downregulated. McClellan SA, Zhang Y, Barrett RP, et al. Invest. Ophthalmol. Vis. Sci. 49(4), 1502-11, (2008)
Spantide I decreases type I cytokines, enhances IL-10, and reduces corneal perforation in susceptible mice after Pseudomonas aeruginosa infection. Hazlett LD, McClellan SA, Barrett RP, et al. Invest. Ophthalmol. Vis. Sci. 48(2), 797-807, (2007)
Substance P injected into the dorsal periaqueductal gray causes anxiogenic effects similar to the long-term isolation as assessed by ultrasound vocalizations measurements. Bassi GS, Nobre MJ, Carvalho MC, et al. Behav. Brain Res. 182(2), 301-7, (2007)
Comparison of antagonist activity of spantide family at human neurokinin receptors measured by aequorin luminescence-based functional calcium assay. Janecka A, Poels J, Fichna J, et al. Regul. Pept. 131(1-3), 23-8, (2005)
Substance P regulates natural killer cell interferon-gamma production and resistance to Pseudomonas aeruginosa infection. Lighvani S, Huang X, Trivedi PP, et al. Eur. J. Immunol. 35(5), 1567-75, (2005)
Solution conformation of Substance P antagonists-[D-Arg1, D-Trp7,9, Leu11]-SP, [D-Arg1, D-Pro2, D-Trp7,9, Leu11]-SP and [D-Pro2, D-Trp7,9]-SP by CD, NMR and MD simulations. Prabhu A, Malde A, Coutinho E, et al. Peptides 26, 875-885, (2005)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?