|Related Categories||Antioxidant, Cell Biology, Chemical Synthesis, Functional Foods, Inorganic Salts,|
|suitability||suitable for cell culture|
Sodium selenite is commonly used as a source of selenium in biological research, where selenium is an essential trace element that is normally provided by serum. Selenium is present in selenoproteins such as glutathione peroxidase and thioredoxin reductase, which contain the selenium analog of cysteine, selenocysteine. In particular, glutathione peroxidase has a role in detoxification in vivo as a scavenger of peroxides. Sodium selenite has been utilized in studies of cell proliferation and cancer research. It has been used to alter gene expression in HepG2 cells as analyzed by cDNA microarrays. Sodium selenite can inhibit zinc finger protein/DNA interactions. Sodium selenite has been shown to alter mitochondrial membrane potentials and thus potentially contribute to apoptosis.
This product is cell culture tested (0.005 mg/L) and is appropriate for use in cell culture applications.
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Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P264-P273-P280-P301 + P310-P311|
|Supplemental Hazard Statements||Contact with acids liberates toxic gas.|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T+,N|
|Risk Statements (Europe)||23-28-31-43-51/53|
|Safety Statements (Europe)||28-36/37-45-61|
|RIDADR||UN 2630 6.1/PG 1|
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
BioFiles 2007, 2.2, 2.
Keywords: Adhesion, Anti-inflammatory agents, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins
Co-application of selenite and phosphate reduces arsenite uptake in hydroponically grown rice seedlings: toxicity and defence mechanism. Kumar N, Mallick S, Yadava RN, et al. Ecotoxicol. Environ. Saf. 91, 171-9, (2013)
PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells. Luo H, Yang Y, Duan J, et al. Cell Death Dis. 4, e481, (2013)
Bioavailability, toxicity and biotransformation of selenium in midge (Chironomus dilutus) larvae exposed via water or diet to elemental selenium particles, selenite, or selenized algae. Gallego-Gallegos M, Doig LE, Tse JJ, et al. Environ. Sci. Technol. 47(1), 584-92, (2013)
Selenium (sodium selenite) causes cytotoxicity and apoptotic mediated cell death in PLHC-1 fish cell line through DNA and mitochondrial membrane potential damage. Selvaraj V, Tomblin J, Yeager Armistead M, et al. Ecotoxicol. Environ. Saf. 87, 80-8, (2013)
High-dose sodium selenite toxicity cannot be prevented by the co-administration of pharmacological levels of epigallocatechin-3-gallate which in turn aggravates the toxicity. Sun K, Wu S, Wang Y, et al. Food Chem. Toxicol. 52, 36-41, (2013)
Effect of sulfide, selenite and mercuric mercury on the growth and methylation capacity of the sulfate reducing bacterium Desulfovibrio desulfuricans. Truong HY, Chen YW, and Belzile N Sci. Total Environ. 449, 373-84, (2013)
Characterization of cytosolic glutathione peroxidase and phospholipid-hydroperoxide glutathione peroxidase genes in rainbow trout (Oncorhynchus mykiss) and their modulation by in vitro selenium exposure. Pacitti D, Wang T, Page MM, et al. Aquat. Toxicol. 130-131, 97-111, (2013)
Application of reversed-phase high-performance liquid chromatography with fluorimetric detection for simultaneous assessment of global DNA and total RNA methylation in Lepidium sativum: effect of plant exposure to Cd(II) and Se(IV). Yanez Barrientos E, Wrobel K, Lopez Torres A, et al. Anal. Bioanal. Chem 405(7), 2397-404, (2013)
Colostrum and milk selenium, antioxidative capacity and immune status of dairy cows fed sodium selenite or selenium yeast. Salman S, Dinse D, Khol-Parisini A, et al. Arch. Anim. Nutr. 67(1), 48-61, (2013)
Evaluation of pharmacological activities and assessment of intraocular penetration of an ayurvedic polyherbal eye drop (Itone™) in experimental models. Velpandian T, Gupta P, Ravi AK, et al. BMC Complement Altern. Med. 13, 1, (2013)
Selenite stimulates mitochondrial biogenesis signaling and enhances mitochondrial functional performance in murine hippocampal neuronal cells. Mendelev N, Mehta SL, Idris H, et al. PLoS ONE 7(10), e47910, (2012)
Aldrich MSDS 1, 1614:B / Corp MSDS 1 (2), 3153:D / RegBook 1 (3), 3509:H / Sax 6, 2451 / Sigma FT-IR 1 (2), 1047:B
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