S-15176 difumarate salt
≥98% (HPLC), solid
DOWNLOAD MSDS (PDF)Synonym:
N-[(3,5-Di-tert-
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CAS Number 148913-55-7
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Linear Formula C31H48N2O4S · 2 C4H4O4
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Molecular Weight 776.93
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MDL number MFCD11046049
Properties
| Related Categories | Apoptosis Inhibitors, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, |
| assay | ≥98% (HPLC) |
| form | solid |
| solubility | DMSO: soluble16 mg/mL |
| H2O: insoluble | |
| storage temp. | 2-8°C |
Description
Biochem/physiol Actions
Antioxidant and anti-ischemic agent. Also inhibits mitochondrial permeability transition, prevents the early step in apoptosis by preventing collapse of the electrochemical gradient across the mitochondrial membrane. IC50 for in vitro lipid peroxidation is 0.3 μM. IC50 for carnitine palmitoyltransferase (CPT-1) in heart homogenate is 16.8 μM. The shift from fatty acid to glucose oxidation may contribute to anti-ischemic effect.
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