|Related Categories||Aminoglycosides, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S,|
|potency||≥603 μg per mg|
Used as a selection agent for transformed plant cells that contain the selectable marker gene Spcr and to inhibit bacterial protein synthesis at the level of peptidy tRNA translocation.
Mode of Action: Inhibits protein synthesis (elongation) by interfering with peptidyl tRNA translocation.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria (Gonnococcus only).
Mode of Resistance: Mutation in rpsE (the gene for ribosomal protein S5) prevents binding of spectinomycin.
Spectinomycin is a broad spectrum antibiotic that inhibits protein synthesis (elongation) by binding to the bacterial 30S ribosomal subunit and interfering with peptidyl tRNA translocation. Resistance to spectinomycin is conferred by aminoglycoside-3′-adenylt
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Ready Made Solution, 100 mg/mL in DMSO/H2O, 1:1, 0.2 μm filtered
powder, BioReagent, suitable for cell culture
VETRANAL™, analytical standard
Certificate of Analysis
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Increasing antibiotic resistance and the lack of new drug development have hindered the success of antibiotics in recent years. Staph aureus is susceptible to a number of antibiotics with various mec...
In vitro activities of spectinomycin and comparator agents against Pasteurella multocida and Mannheimia haemolytica from respiratory tract infections of cattle Stefan Schwarz, Corinna Kehrenberg, et al. J. Antimicrob. Chemother. 53, 379-382, (2004)
Study of Plastid Genome Stability in Tobacco Reveals That the Loβ of Marker Genes Is More Likely by Gene Conversion Than by Recombination between 34-bp loxP Repeats Tarinee Tungsuchat-Huang, et al. Plant Physiol. 153, 252 - 259, (2010)
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