|Related Categories||Aminoglycosides, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S,|
|potency||≥603 μg per mg|
Used as a selection agent for transformed plant cells that contain the selectable marker gene Spcr and to inhibit bacterial protein synthesis at the level of peptidy tRNA translocation.
Mode of Action: Inhibits protein synthesis (elongation) by interfering with peptidyl tRNA translocation.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria (Gonnococcus only).
Mode of Resistance: Mutation in rpsE (the gene for ribosomal protein S5) prevents binding of spectinomycin.
Spectinomycin is a broad spectrum antibiotic that inhibits protein synthesis (elongation) by binding to the bacterial 30S ribosomal subunit and interfering with peptidyl tRNA translocation. Resistance to spectinomycin is conferred by aminoglycoside-3′-adenylt
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Ready Made Solution, 100 mg/mL in DMSO/H2O, 1:1, 0.2 μm filtered
powder, BioReagent, suitable for cell culture
VETRANAL™, analytical standard
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Increasing antibiotic resistance and the lack of new drug development have hindered the success of antibiotics in recent years. Staph aureus is susceptible to a number of antibiotics with various mec...
In vitro activities of spectinomycin and comparator agents against Pasteurella multocida and Mannheimia haemolytica from respiratory tract infections of cattle Stefan Schwarz, Corinna Kehrenberg, et al. J. Antimicrob. Chemother. 53, 379-382, (2004)
Study of Plastid Genome Stability in Tobacco Reveals That the Loβ of Marker Genes Is More Likely by Gene Conversion Than by Recombination between 34-bp loxP Repeats Tarinee Tungsuchat-Huang, et al. Plant Physiol. 153, 252 - 259, (2010)
Multiplex bead suspension array for screening Neisseria gonorrhoeae antibiotic resistance genetic determinants in noncultured clinical samples. Balashov S, Mordechai E, Adelson ME, et al. J. Mol. Diagn. 15(1), 116-29, (2013)
[Detection and the antibiotic susceptibility analysis of mycoplasma and chlamydia in urogenital tract infections of 327 cases patients with tubal infertility]. Zhou Y, Xu XL, Wang CP, et al. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 25(3), 201-4, (2011)
In vitro antimicrobial inhibition of Mycoplasma bovis isolates submitted to the Pennsylvania Animal Diagnostic Laboratory using flow cytometry and a broth microdilution method. Soehnlen MK, Kunze ME, Karunathilake KE, et al. J. Vet. Diagn. Invest. 23(3), 547-51, (2011)
Development and validation of liquid chromatography tandem mass spectrometry methods for the determination of gentamicin, lincomycin, and spectinomycin in the presence of their impurities in pharmaceutical formulations. Vučićević-Prčetić K, Cservenák R, and Radulović N J. Pharm. Biomed. Anal. 56(4), 736-42, (2011)
2-Oxoglycosyl ("ulosyl") and 2-oximinoglycosyl bromides: versatile donors for the expedient assembly of oligosaccharides with β-D-mannose, β-L-rhamnose, N-acetyl-β-D-mannosamine, and N-acetyl-β-D-mannosaminuronic acid units. Lichtenthaler FW Chem. Rev. 111(9), 5569-609, (2011)
The Neisseria gonorrhoeae photolyase orthologue phrB is required for proper DNA supercoiling but does not function in photo-reactivation. Cahoon LA, Stohl EA, and Seifert HS Mol. Microbiol. 79(3), 729-42, (2011)
Simultaneous determination of lincomycin and spectinomycin residues in animal tissues by gas chromatography-nitrogen phosphorus detection and gas chromatography-mass spectrometry with accelerated solvent extraction. Tao Y, Chen D, Yu G, et al. Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 28(2), 145-54, (2011)
Neisseria gonorrhoeae strain with high-level resistance to spectinomycin due to a novel resistance mechanism (mutated ribosomal protein S5) verified in Norway. Unemo M, Golparian D, Skogen V, et al. Antimicrob. Agents Chemother. 57(2), 1057-61, (2013)
Physiologic consequences of glucose transport and phosphoenolpyruvate node modifications in Bacillus subtilis 168. Cabrera-Valladares N, Martínez LM, Flores N, et al. J. Mol. Microbiol. Biotechnol. 22(3), 177-97, (2012)
Visual spectinomycin resistance (aadA(au)) gene for facile identification of transplastomic sectors in tobacco leaves. Tungsuchat-Huang T, Slivinski KM, Sinagawa-Garcia SR, et al. Plant Mol. Biol. 76(3-5), 453-61, (2011)
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