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SCP0193 Sigma

MMP Substrate

≥97% (HPLC)

DOWNLOAD MSDS (PDF)

Synonym: FS-6

  • Empirical Formula (Hill Notation) C55H80N16O16

  • Molecular Weight 1221.32

Description

Amino Acid Sequence

MCA-Lys-Pro-Leu-Gly-Leu-DNP-Dpa-Ala-Arg-NH2

Biochem/physiol Actions

The peptide MCA-Lys-Pro-Leu-Gly-Leu-DNP-Dpa-Ala-Arg-NH2, or FS-6, is a fluorogenic substrate for several matrix metalloproteinases (MMP). FS-6 is a modified form of the well-established MMP substrate FS-1, where a lysine residue has been added to the N-terminus of FS-1. The resulting FS-6 has been reported to give a peptide with improved kinetic properties for several MMPs, including MMP-1, MMP-8, MMP-13, and MMP-14, compared to FS-1. FS-6 has also been described as a particularly useful substrate for the zinc metalloproteinase TACE (ADAM-17).

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