Empirical Formula (Hill Notation) C21H18O12 · xH2O
Molecular Weight 462.36 (anhydrous basis)
|Related Categories||Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Flavonoids, Flavonols, and Flavanols, Kinase/Phosphatase Biology,|
|solubility||DMSO: ≥10 mg/mL|
Scutellarin is a flavonoid that exhibits a number of cardio- and neuro-protective effects. Scutellarin inhibits p38 activity, ERK phosphorylation, and TGF-β expression and fibrosis in a rat myocardial infarct model. In a cerebral ischemia-reperfusion model, the compound reduced infarct volume and neurological deficits by increasing eNOS expression while inhibiting the induction of iNOS.
Scutellarin hydrate may be used in MAPK-mediated cell signaling studies.
Scutellarin alleviates interstitial fibrosis and cardiac dysfunction of infarct rats by inhibiting TGFβ1 expression and activation of p38-MAPK and ERK1/2. Pan, Z., et al. Br. J. Pharmacol. 162, 688-700, (2011)
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