PDI inhibitor 16F16
≥98% (HPLC)
DOWNLOAD MSDS (PDF)Synonym:
2-
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CAS Number 922507-80-0
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Empirical Formula (Hill Notation) C16H17ClN2O3
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Molecular Weight 320.77
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MDL number MFCD20134198
Properties
| Related Categories | Apoptosis Inhibitors, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to tan |
| solubility | DMSO: ≥12 mg/mL |
| storage temp. | 2-8°C |
Description
Biochem/physiol Actions
16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation.
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>95% (SDS-PAGE), 100-400 units/mg protein, lyophilized powder
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