|Related Categories||Apoptosis Inhibitors, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,|
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R18 is a competitive inhibitor of the 14-3-3 scaffolding proteins. It binds to the general binding groove of 14-3-3. R18 blocks 14-3-3 interaction with most or all of its client proteins.
A NEW NON-PEPTIDIC INHIBITOR OF THE 14-3-3 DOCKING SITE INDUCES APOPTOTIC CELL DEATH IN CHRONIC MYELOID LEUKEMIA SENSITIVE OR RESISTANT TO IMATINIB. Mancini M, Corradi V, Petta S, Barbieri E, Manetti F, Botta M, Santucci MA. J. Pharmacol. Exp. Ther., (2010)
A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex. Mu FT, Andrews RK, Arthur JF, Munday AD, Cranmer SL, Jackson SP, et al. Blood 9, 4580-7, (2008)
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