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SML0499 Sigma

NCTT-956

≥97% (NMR)

Synonym: N-[(8-Hydroxy-5-nitro-7-quinolinyl)-2-thienylmethyl]-propanamide

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Properties

Related Categories Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   DEXNORPUTBBNSC-UHFFFAOYSA-N
assay   ≥97% (NMR)
form   powder
color   light orange to dark orange
solubility   DMSO: 5 mg/mL (clear solution)
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

NCTT-956 is a very potent, specific inhibitor of 12-lipoxygenase (12-LO) activity, with an IC50 of 800 nM, no activity against 5-LO and greater than 25-fold selectivity over 15-LO. Specific inhibition of 12-LO by NCTT-956 in platelets blocks PKC activation, aggregation, granule secretion and αIIbB3 activation.

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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