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SML0890 Sigma

SB 452533

≥98% (HPLC)

Synonym: N-(2-Bromophenyl)-N′-[2-[ethyl(3-methylphenyl)amino]ethyl]urea, SB-452533

  • CAS Number 459429-39-1

  • Empirical Formula (Hill Notation) C18H22BrN3O

  • Molecular Weight 376.29

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Neurobiology,
assay   ≥98% (HPLC)
form   powder
color   yellow to orange
solubility   DMSO: 20 mg/mL clear
storage temp.   room temp

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

SB-452533 acts as a competitive inhibitor at the capsaicin binding site on the transient receptor potential channel TRPV1 receptor with a pKb of 7.7 versus capsaicin and pIC50 of 7.0 versus pH. At higher concentrations, SB-452533 is also active at TRPM8 with an IC50 of 571 nM. It has a high clearance rate, so is not suitable for in vivo use.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Safety Information

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UN 3077 9 / PGIII
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Documents

Certificate of Analysis

Protocols & Articles

Articles

Discover Bioactive Small Molecules for Neuroscience

The nervous system, comprised of the brain and spinal cord (central nervous system, or CNS) and network of nerves that connects the CNS to the rest of the body (peripheral nervous system, or PNS) is ...
Keywords: Bioactive small molecules, Central Nervous System, Diseases, Metabolism, Neurodegenerative Diseases, Neuroscience, Neurotransmission, Neurotransmitters

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