Synonym: HD5, Histone deacetylase 5, NY-CO-9
|Related Categories||Cell Biology, Cell Signaling and Neuroscience, Deacetylases, Epigenetics, Histone Modifying Enzymes,|
|recombinant||expressed in baculovirus infected insect cells|
|mol wt||mol wt 150 kDa|
|NCBI accession no.||NM_001015053|
|shipped in||dry ice|
|Gene Information||human ... HDAC5(10014)|
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Human HDAC5, GenBank Accession No. NM_001015053, full length with N-terminal ST tag, MW = 150 kDa, expressed in baculovirus expression system.
Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.
One unit is defined as the amount of enzyme required to deacetylate 1 pmol of substrate/min at 37°C.
Formulated in 25 mM Tris-HCl, pH 8.0, 138 mM NaCl, 0.05% Tween-20 and 10% glycerol.
Huntington's disease (HD) is an autosomal dominant, late-onset neurodegenerative disorder characterized by a selective neuronal cell death in the cortex and striatum leading to cognitive dysfunction,...
Carolyn L. Crankshaw
BioFiles v7 n2, 2011, 9–14
Keywords: Apoptosis, Huntington Disease, Transcription
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