BRCA1 human recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

Properties

Related Categories	Cell Biology, Cell Signaling and Neuroscience, Gene Regulation and Expression, Transcription Factors
recombinant	expressed in insect cells
assay	≥70% (SDS-PAGE)
form	frozen liquid
mol wt	mol wt ~209 kDa
NCBI accession no.	NM_007296
shipped in	dry ice
storage temp.	−70°C
Gene Information	human ... BRCA1(672)

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Description

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Physical form

Clear and colorless frozen liquid solution

Biochem/physiol Actions

The human BRCA1, the product of breast and ovarian cancer gene 1, is a hyperphosphorylated protein functioning as a tumor suppressor involved in both transcription regulation and DNA repair. BRCA1 associates with RAD51 and has shown to be required for transcription-coupled repair of DNA damage as well as for the repair of chromosomal double-strand breaks. Association with a human SWI/SNF-related complex has recently suggested a potential role of BRCA1 in linking chromatin remodeling to breast cancer.