Synonym: Isoopeptidase T, Isopeptidase T (short form), IsopeptidaseT, USP5, Ubiquitin-specific protease 5
|Related Categories||Cell Biology, Cell Signaling and Neuroscience, Intracellular Protein Degradation, Nitric Oxide and Cell Stress, Ubiquitin and Proteases More...|
|recombinant||expressed in E. coli|
|mol wt||mol wt 93.4 kDa|
|NCBI accession no.||P45974|
|shipped in||dry ice|
|Gene Information||human ... UBP5(8078)|
Ubiquitin C-terminal hydrolases (UCHs) are a family of cysteine hydrolases that catalyze the UBPs hydrolyze isopeptide bonds between ubiquitin and the substrate protein or within polyubiquitin chains. Human isopeptidase T (isoT) is an UBP capable of binding ubiquitin that specifically disassembles free polyubiquitin chains linked through isopeptide bonds involving the K48 of ubiquitin into ubiquitin monomers.
Supplied at a concentration of 2.0 mg/ml in 50 mM Tris, 10 mM ?-mercaptoethanol, pH 7.5.
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