|Related Categories||Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Substrates,|
|concentration||1 mg/mL in chloroform/methanol (2:1)|
Substrate for microbial and animal sphingomyelinases.
TNPAL-Sphingomyelin was used as substrate to determine the activity of sphingomyelinase spectrophotometrically.1,2,3
Sphingomyelin (SM) is a sphingolipid found in the myelin sheath and cell membranes of animals. The regulation of SM content by sphingomyelinase and SM synthase 2 affect the membrane properties and signaling.4 Excess oxysterols result in increased amount of SM and calcium ions that is the main reason for artery blockage and atherosclerosis.5
Certificate of Analysis
Certificate of Origin
|Symbol||GHS02, GHS06, GHS08|
|Precautionary statements||P210-P260-P280-P301 + P310-P307 + P311|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter|
|Hazard Codes (Europe)||F,T|
|Risk Statements (Europe)||11-23/24/25-38-39/23/24/25-40-48/20/22|
|Safety Statements (Europe)||16-36/37-45|
|RIDADR||UN 1992 3/PG 2|
|Flash Point(F)||51.8 °F|
|Flash Point(C)||11 °C|
1. Effect of endurance training on the sphingomyelin-signalling pathway activity in the skeletal muscles of the rat. Dobrzyń A, Zendzian-Piotrowska M, and Górski J J. Physiol. Pharmacol. 55(2), 305-13, (2004)
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