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T7080 Sigma

Tazarotene

≥98% (HPLC)

DOWNLOAD MSDS (PDF)

Synonym: 6-[(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylic acid ethyl ester, AGN-190168, ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl] nicotinate

  • CAS Number 118292-40-3

  • Empirical Formula (Hill Notation) C21H21NO2S

  • Molecular Weight 351.46

Properties

Related Categories Allergan, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   powder
color   white to very faintly yellow
solubility   DMSO: >15 mg/mL
storage temp.   2-8°C

Description

Biochem/physiol Actions

Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. It is a prodrug of tazarotenic acid, which specifically activates RARb and RARg, only weakly activates RARa, and is inactive at retinoid X receptors (RXRs). In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation.

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