CAS Number 118292-40-3
Empirical Formula (Hill Notation) C21H21NO2S
Molecular Weight 351.46
|Related Categories||Allergan, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,|
|color||white to very faintly yellow|
|solubility||DMSO: >15 mg/mL|
Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. It is a prodrug of tazarotenic acid, which specifically activates RARb and RARg, only weakly activates RARa, and is inactive at retinoid X receptors (RXRs). In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation.
Efficacy of pulsed dye laser plus topical tazarotene versus topical tazarotene alone in psoriatic nail disease: a single-blind, intrapatient left-to-right controlled study. Huang YC, Chou CL, and Chiang YY Lasers Surg. Med. 45(2), 102-7, (2013)
A randomized trial of the off-label use of imiquimod, 5%, cream with vs without tazarotene, 0.1%, gel for the treatment of lentigo maligna, followed by conservative staged excisions. Hyde MA, Hadley ML, Tristani-Firouzi P, et al. Arch. Dermatol. 148(5), 592-6, (2012)
Effect of retinoid pretreatment on outcomes of patients treated by photodynamic therapy for actinic keratosis of the hand and forearm. Galitzer BI Journal. of. Drugs in. Dermatology. 10(10), 1124-32, (2011)
Establishment of murine basal cell carcinoma allografts: a potential model for preclinical drug testing and for molecular analysis. Wang GY, So PL, Wang L, et al. J. Invest. Dermatol. 131(11), 2298-305, (2011)
Stability-indicating spectrophotometric methods for determination of tazarotene in the presence of its alkaline degradation product by derivative spectrophotometric techniques. Badawy AM, El-Alim Ael-A, and Saad AS Drug Test. Anal. 2(3), 130-6, (2010)
Rapid improvement in digital ischemia and acral contracture in a collodion baby treated with topical tazarotene. Liu RH, Becker B, Gunkel J, et al. Journal. of. Drugs in. Dermatology. 9(6), 713-6, (2010)
Evaluation of the antipsoriatic activity of Aloe vera leaf extract using a mouse tail model of psoriasis. Dhanabal SP, Priyanka Dwarampudi L, Muruganantham N, et al. Phytother Res. 26(4), 617-9, (2012)
Clinical evidence for the role of a topical anti-inflammatory agent in comedonal acne: findings from a randomized study of dapsone gel 5% in combination with tazarotene cream 0.1% in patients with acne vulgaris. Tanghetti E, Dhawan S, Green L, et al. Journal. of. Drugs in. Dermatology. 10(7), 783-92, (2011)
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