CAS Number 118292-40-3
Empirical Formula (Hill Notation) C21H21NO2S
Molecular Weight 351.46
|Related Categories||Allergan, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,|
|color||white to very faintly yellow|
|solubility||DMSO: >15 mg/mL|
Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. It is a prodrug of tazarotenic acid, which specifically activates RARb and RARg, only weakly activates RARa, and is inactive at retinoid X receptors (RXRs). In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation.
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