Synonym: Urate oxidase, Urate:O2 oxidoreductase
|Related Categories||1.7.x.x Other nitrogenous donors, 1.x.x.x Oxidoreductases, Biochemicals and Reagents, Cell Biology, Enzyme Class Index,|
One unit will convert 1.0 μmole of uric acid to allantoin per min at pH 9.0 at 25 °C.
Molecular weight: 4 × ~32 KDa (tetramer)
Isoelectric point: is 4.64
KM value (uric acid as substrate): ~ 0.01 mM
The optimum pH for activity: 8.5-9.5
The optimum pH for stability: 6.0-9.5
Zn and Cu were shown to inhibit the activity of uricase.
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lyophilized, ~9 U/mg
~15 units/g protein (biuret)
recombinant, expressed in E. coli, lyophilized powder, ≥2 units/mg solid
Type V, soluble powder, ≥10 units/g protein
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Uricase from Bacillus fastidious loaded in alkaline enzymosomes: enhanced biochemical and pharmacological characteristics in hypouricemic rats. Tan Q, Zhang J, Wang N, et al. Eur. J. Pharm. Biopharm. 82(1), 43-8, (2012)
Pre-treatment with allopurinol or uricase attenuates barrier dysfunction but not inflammation during murine ventilator-induced lung injury. Kuipers MT, Aslami H, Vlaar AP, et al. PLoS ONE 7(11), e50559, (2012)
Structural and mechanistic studies of HpxO, a novel flavin adenine dinucleotide-dependent urate oxidase from Klebsiella pneumoniae. Hicks KA, O'Leary SE, Begley TP, et al. Biochemistry 52(3), 477-87, (2013)
Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats. Tapia E, Cristóbal M, García-Arroyo FE, et al. Am. J. Physiol. Renal Physiol. 304(6), F727-36, (2013)
Alternative treatment for chronic gout could relieve pain for thousands. The recently approved intravenous drug, pegloticase, may work when other treatments don't. Duke. Med. Health. News. 19(1), 3, (2013)
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