|Related Categories||Books and Software, Labware, Organic Chemistry Books More...|
|publication info||M. Sierra, M. de la Torre, K. C. Nicolaou (Foreward by), John Wiley & Sons, 2005, 290 pp., soft cover|
|packaging||pkg of 1 ea|
In almost all publications, the valuable information provided is almost always based on successful organic reactions. However, a chemist′s life is not that easy. Trial and error is still one of the most commonly used methods. Thus it would be useful to have access to those syntheses that do not work, since they also provide important results of great importance for further synthesis. This book fills just such a gap. Using major total syntheses, the authors explain a variety of problems and recommend ways out of such dilemmas: Problems at the start and end of a synthesis, difficult and unexpected reactivities of functional groups, problems due to steric properties and much more. The result is a wealth of information for any organic chemist and an essential tool for successful total synthesis.
Chapter 1: Introduction: From the Paper to the Laboratory.
Chapter 2: Tuning-up, Tactical and Strategic Changes.
2.1 Tuning-up Reaction Conditions.
2.2 Tactical Changes.
2.3 Strategic Changes.
Chapter 3: Working with Models.
3.3 (+)-Damavaricin D.
3.4 Dynemicin A.
Chapter 4: The Unexpected Reactivity or Inertia of Common Functional Groups.
4.2 Octalactins A and B.
4.3 (�)-Polycavernoside A.
Chapter 5: The Influence of Remote Substituents.
5.1 �Alive� Dead Steric Volume.
5.2 The Reactive Remote Group.
Chapter 6: The Elusive Side Chain.
6.1 (±)-Scopadulcic Acid B.
Chapter 7: The Unpredictable Stereochemistry.
7.1 Nocardiones A and B.
7.3 Hamigerans A and B.
7.4 Calphostin A.
7.5 Fragment C3-C10 of Cytovaricin.
Chapter 8: Reluctant Ring Closures.
8.1 Discorhabdin C.
8.2 Discorhabdin A.
8.3 Frondosin B.
8.6 Roseophilin Tricyclic Core: The Formal Total Synthesis of Roseophilin.
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