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  • A0401 - Adrenocorticotropic Hormone Fragment 4-10 human, rat

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A0401 Sigma

Adrenocorticotropic Hormone Fragment 4-10 human, rat

≥97% (HPLC)

Synonym: ACTH4-10

  • CAS Number 4037-01-8

  • Empirical Formula (Hill Notation) C44H59N13O10S

  • Molecular Weight 962.09

  •  MDL number MFCD00167482

  •  PubChem Substance ID 24890423

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Properties

Related Categories Adrenocorticotropic Hormones (ACTH), Cell Biology, Cell Signaling and Neuroscience, Peptides and Proteins, Peptides for Cell Biology More...
InChI Key   HAAUASBAIUJHAN-UHFFFAOYSA-N
assay   ≥97% (HPLC)
storage temp.   −20°C
Gene Information   human ... POMC(5443)
rat ... Crhr2(64680)

Description

Amino Acid Sequence

Met-Glu-His-Phe-Arg-Trp-Gly

Other Notes

Core fragment of ACTH, α- and β-MSH, and β-lipotropin

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Quality

Lacks adrenocorticotropic activity.

Biochem/physiol Actions

Adrenocorticotropic Hormone Fragment 4-10 (ACTH (4-10)) attenuates ischemia/reperfusion-induced cardiac injury via reduction in infarct size, caspase 3 activity, and apoptosis, and an increase in HO-1 expression. ACTH 4-10 is a melanocortin 4 receptor (MCR-4) agonist. ACTH 4-10 facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval. ACTH 4-10 and semax are analogues.

Adrenocorticotropic Hormone Fragment 4-10 [ACTH(4-10)], a melanocortin fragment, is used together with its analogue semax to study the processes of nociception/pain sensation and brain development. ACTH(4-10) is also used as a possible anorexic factor. It facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval.

Price and Availability


Amplified Detection

All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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