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A0606 Sigma

Aurothioglucose hydrate

≥96% (titration)

Synonym: Gold thioglucose, Solganal, Solganol

  • CAS Number 12192-57-3 (anhydrous)

  • Empirical Formula (Hill Notation) C6H11AuO5S · xH2O

  • Molecular Weight 392.18 (anhydrous basis)

  •  PubChem Substance ID 24724383

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Properties

Related Categories AN-AZ, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   SGVIEHTYEMEDRR-PKXGBZFFSA-M
assay   ≥96% (titration)
form   powder
storage condition   desiccated
color   white to beige
solubility   H2O: 5 mg/mL clear
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Aurothioglucose, a gold compound used clinically to treat rheumatoid arthritis, has recently been found to be a potent PKCiota-Par6 interaction inhibitor, with an IC50 approximately 1 μM. Disruption of this interaction disrupts a rac1 signaling pathway that is required for transformed growth in non-small-cell lung cancer.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

PKC

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins. It was first identified in 1977 in bovine cerebellum by Nishizuka and co-workers as ...
Keywords: Apoptosis, Atomic absorption spectroscopy, Biological processes, Cancer, Catalysis, Cell signaling, Degradations, Diabetes, Gastrointestinal, Gene expression, Immobilization, Phosphorylations, Pulsed discharge ionization detector, Transcription, Ubiquitinations

Peer-Reviewed Papers
15

References

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