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A0638 Sigma

Adipic acid dihydrazide

≥98% (titration)

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Properties

Related Categories Chemical Biology, Chemical Synthesis, Crosslinkers, Crosslinking, Homobifunctional Cross-Linking Reagents,
InChI Key   IBVAQQYNSHJXBV-UHFFFAOYSA-N
Quality Level   PREMIUM
assay   ≥98% (titration)
mp   180-182 °C(lit.)
solubility   H2O: soluble100 mg/mL
storage temp.   −20°C

Description

Other Notes

Note that the hydrazone bond may be stabilized by selective reduction using, for example, sodium cyanoborohydride.

Packaging

25, 100 g in poly bottle

Application

Adipic acid dihydrazide is a homobifunctional cross-linking reagent specific for aldehydes resulting in relatively stable hydrazone linkages. Adipic acid dihydrazide is typically, used in the linking of glycoproteins, such as antibodies, in a site specific fashion following periodate oxidation. Oxidation and coupling may conveniently be performed at pH 5.0 due to the low pKa of the hydrazide which avoids competition by primary amines.

Price and Availability


Amplified Detection
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Flash Point(F) 
302 °F
Flash Point(C) 
150 °C

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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Product #

Description

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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