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A0737 Sigma

N-acetylcysteine amide

≥98% (HPLC)

DOWNLOAD MSDS (PDF)

Synonym: (R)- 2-(Acetylamino)-3-mercapto-Propanamide, AD4, N-Acetyl-L-cysteinamide, NACA, acetylcysteinamide

  • CAS Number 38520-57-9

  • Empirical Formula (Hill Notation) C5H10N2O2S

  • Molecular Weight 162.21

  •  MDL number MFCD01696115

N-acetylcysteine amide ≥98% (HPLC)
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Properties

Related Categories A-AM, Antioxidants and Cytoprotectants, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to off-white
solubility   H2O: ≥20 mg/mL
  DMSO: >40 mg/mL
storage temp.   2-8°C

Description

Other Notes

This product is hydroscopic and air sensitive.

Biochem/physiol Actions

N-acetylcysteine amide is a membrane penetrating antioxidant with antiinflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS. The compound readily crosses cell membranes, replenishes intracellular GSH, and defends the cell from oxidative stress. In contrast to DTT, AD4 is able to directly reduce intracellularl GSSG to GSH without the involvement of glutathione peroxidase. Such direct thiol exchange might have a protective effect. This compound has a potential in research and exploration for treatment of neurodegeneration, radiation exposure, and other oxidation-mediated disorders.

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