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  • A0737 - N-acetylcysteine amide

A0737 Sigma

N-acetylcysteine amide

≥98% (HPLC)

Synonym: (R)- 2-(Acetylamino)-3-mercapto-Propanamide, AD4, N-Acetyl-L-cysteinamide, NACA, acetylcysteinamide

  • CAS Number 38520-57-9

  • Empirical Formula (Hill Notation) C5H10N2O2S

  • Molecular Weight 162.21

  •  MDL number MFCD01696115



Related Categories A-AM, Antioxidants and Cytoprotectants, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to off-white
solubility   H2O: ≥20 mg/mL
  DMSO: >40 mg/mL
storage temp.   2-8°C


Other Notes

This product is hydroscopic and air sensitive.

Biochem/physiol Actions

N-acetylcysteine amide is a membrane penetrating antioxidant with antiinflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS. The compound readily crosses cell membranes, replenishes intracellular GSH, and defends the cell from oxidative stress. In contrast to DTT, AD4 is able to directly reduce intracellularl GSSG to GSH without the involvement of glutathione peroxidase. Such direct thiol exchange might have a protective effect. This compound has a potential in research and exploration for treatment of neurodegeneration, radiation exposure, and other oxidation-mediated disorders.

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Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles


Discover Bioactive Small Molecules for Nitric Oxide Cell & Stress Research

Exposure to harsh conditions, cellular damage, and other factors can cause stress on cells. Stress attributed directly and indirectly to oxygen is referred to as oxidative stress, which is imposed on...
Keywords: Antimicrobials, Bioactive small molecules, Cancer, Diseases, Neurodegenerative Diseases, Oxidations

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