• USA Home
  • A0737 - N-acetylcysteine amide


A0737 Sigma

N-acetylcysteine amide

≥98% (HPLC)

Synonym: (R)- 2-(Acetylamino)-3-mercapto-Propanamide, AD4, N-Acetyl-L-cysteinamide, NACA, acetylcysteinamide

  • CAS Number 38520-57-9

  • Empirical Formula (Hill Notation) C5H10N2O2S

  • Molecular Weight 162.21

  •  MDL number MFCD01696115


Related Categories A-AM, Antioxidants and Cytoprotectants, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to off-white
solubility   H2O: ≥20 mg/mL
  DMSO: >40 mg/mL
storage temp.   2-8°C


Other Notes

This product is hydroscopic and air sensitive.

Biochem/physiol Actions

N-acetylcysteine amide is a membrane penetrating antioxidant with antiinflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS. The compound readily crosses cell membranes, replenishes intracellular GSH, and defends the cell from oxidative stress. In contrast to DTT, AD4 is able to directly reduce intracellularl GSSG to GSH without the involvement of glutathione peroxidase. Such direct thiol exchange might have a protective effect. This compound has a potential in research and exploration for treatment of neurodegeneration, radiation exposure, and other oxidation-mediated disorders.

Price and Availability

Customers Also Viewed


United States Pharmacopeia (USP) Reference Standard


European Pharmacopoeia (EP) Reference Standard


pharmaceutical secondary standard; traceable to USP, PhEur and BP


PharmaGrade, Ajinomoto, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production, suitable for cell culture


BioXtra, ≥99% (TLC)

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?