|Related Categories||A-AM, Antioxidants and Cytoprotectants, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,|
|color||white to off-white|
|solubility||H2O: ≥20 mg/mL|
|DMSO: >40 mg/mL|
This product is hydroscopic and air sensitive.
N-acetylcysteine amide is a membrane penetrating antioxidant with antiinflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS. The compound readily crosses cell membranes, replenishes intracellular GSH, and defends the cell from oxidative stress. In contrast to DTT, AD4 is able to directly reduce intracellularl GSSG to GSH without the involvement of glutathione peroxidase. Such direct thiol exchange might have a protective effect. This compound has a potential in research and exploration for treatment of neurodegeneration, radiation exposure, and other oxidation-mediated disorders.
A novel thiol compound, N-acetylcysteine amide, attenuates allergic airway disease by regulating activation of NF-kappaB and hypoxia-inducible factor-1alpha. Lee, K.S., et al. Exp. Mol. Med. 39, 756-768, (2007)
N-acetylcysteine amide, a novel cell-permeating thiol, restores cellular glutathione and protects human red blood cells from oxidative stress. Grinberg, L., et al. Free Radic. Biol. Med. 38, 136-145, (2005)
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