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A0781 Sigma

Aphidicolin from Nigrospora sphaerica

≥98% (HPLC), powder

Synonym: APC

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Properties

Related Categories AN-AZ, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application,
InChI Key   NOFOAYPPHIUXJR-APNQCZIXSA-N
Quality Level   PREMIUM
assay   ≥98% (HPLC)
form   powder
optical activity   [α]27/D +12°, c = 1 in methanol(lit.)
color   white
mp   227-233 °C(lit.)
solubility   ethanol: soluble1 mg/mL (stable at least a week at 4°C.)
  DMSO: soluble10 mg/mL (stable at least six weeks at −20°C.)
  methanol: soluble10 mg/mL
  H2O: insoluble
Mode of action   DNA synthesis | interferes
storage temp.   2-8°C
Gene Information   human ... POLA1(5422), POLD1(5424), POLG(5428)

Description

Biochem/physiol Actions

Aphidicolin is an antibiotic, a potent antiviral and antimitotic agent and DNA polymerase inhibitor.

Caution

Estimated shelf-life is two years. For optimal stability, it should be protected from light and stored desiccated.

Packaging

1, 5, 10 mg in glass bottle

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Price and Availability


DISCOVER Bioactive Small Molecules

Flow Cytometry Instruments

All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
PB9185000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Discover Bioactive Small Molecules for Apoptosis

Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Clinical, Diseases, Ligands, Neurodegenerative Diseases

Discover Bioactive Small Molecules for Cell Cycle Research

In proliferating cells, the cell cycle consists of four phases. Gap 1 (G1) is the interval between mitosis and DNA replication that is characterized by cell growth. Replication of DNA occurs during t...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Cell division, Cell proliferation, DNA replication, Diseases, Genetic

Peer-Reviewed Papers
15

References

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