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A0912 Sigma

D-Ala-D-Ala

  • CAS Number 923-16-0

  • Empirical Formula (Hill Notation) C6H12N2O3

  • Molecular Weight 160.17

  •  MDL number MFCD00066038

  •  PubChem Substance ID 24890468

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Properties

Related Categories Biochemicals and Reagents, Dipeptides, Dipeptides and Tripeptides, Peptides
InChI Key   DEFJQIDDEAULHB-QWWZWVQMSA-N
storage temp.   −20°C

Description

Biochem/physiol Actions

D-Ala-D-Ala is found in the stem termini of peptidoglycan side-chain pentapeptide found in the cell walls of gram positive bacteria. The D-ala-d-ala stem termini is the site of interaction of glycopeptide antibiotics such as vancomycin and teicoplanin. D-ala-D-ala is a substrate used to study kinetics of UDPMurNAc-tripeptide D-alanyl-D-alanine-adding (ligase) enzyme.

D-Ala-D-Ala, a terminus moiety of bacterial peptidoglycans, is used for affinity chromatography and binding mechanism studies of antibiotics such as teicoplanin, ristocetin, vancomycin.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A0912.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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