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A0956 Sigma

Angelicin

Synonym: 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran, 2H-Furo[2,3-h]-1-benzopyran-2-one, NSC 404563

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Properties

Related Categories Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience, DNA Intercalators and Crosslinkers, DNA metabolism More...
InChI Key   XDROKJSWHURZGO-UHFFFAOYSA-N
storage temp.   2-8°C

Description

Biochem/physiol Actions

Angular furocoumarin with diverse photobiological effects. Upon long-wavelength UV irradiation, forms monoadduct with double-stranded DNA and reacts with unsaturated fatty acids. Inhibits DNA and RNA synthesis and cell replication in Ehrlich ascites tumor cells.

Packaging

10, 25 mg in poly bottle

Application

Angelicin, an angular furocoumarin, may be used as a photoactivatable molecule that reacts with DNA and unsaturated fatty acids to form monoadducts. Angelicin may be studied as a potential phototherapeutic and to understand its mechanisms of action and effects on RNA and DNA synthesis.

Price and Availability


Flow Cytometry Instruments

All labs need water
Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
LV0940000
Protocols & Articles

Articles

DNA Damage and Repair

Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Degradations, Eliminations, Environmental, Enzymology, Gene expression, Genetic, Infrared spectroscopy, Metabolites, Methylations, Mutagens, Oncology, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription, transformation

Related Content

DNA损伤与修复

突变与癌症的发生均包含细胞DNA损伤过程。人类细胞中的DNA每天都会由于外部(外源)和内部(内源)的代谢进程而遭受成千上百次损伤。细胞基因组的改变可能导致DNA转录过程出现错误,进而通过翻译过程影响到信号转导和细胞功能必需的蛋白质。如果有丝分裂之前这些基因组突变尚未完成修复,则还会进一步遗传给子代细胞。一旦细胞丧失了有效修复DNA损伤的能力,就可能发生三种反应:细胞衰老、细胞凋亡和细胞癌变(参见...
Keywords: Biochemistry, Cancer

Peer-Reviewed Papers
15

References

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