• USA Home
  • A0966 - 4-Amino-1,8-naphthalimide

EMAIL THIS PAGE TO A FRIEND

A0966 Sigma

4-Amino-1,8-naphthalimide

Purchase

Description

Biochem/physiol Actions

4-Amino-1,8-naphthalimide sensitizes cells to radiation-induced cell damage and enhances the cytotoxicity of 1-methyl-3-nitro-1-nitrosoguanidine.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®,1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
WGK Germany 
3
RTECS 
DE4081000

Documents

Certificate of Analysis

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. Banasik, M., et al. J. Biol. Chem. 267, 1569-1575, (1992)

Loading...


4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer. Schlicker, A., et al. Int. J. Radiat. Biol. 75, 91-100, (1999)

Loading...


Combination effects of poly(ADP-ribose) polymerase inhibitors and DNA-damaging agents in ovarian tumor cell lines--with special reference to cisplatin. Bernges, F., and Zeller, W.J. J. Cancer Res. Clin. Oncol. 122, 665-670, (1996)

Loading...


Design and synthesis of a highly sensitive off-on fluorescent chemosensor for zinc ions utilizing internal charge transfer. Hanaoka K, Muramatsu Y, Urano Y, et al. Chemistry 16(2), 568-72, (2010)

Loading...


Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair. Bryant HE and Helleday T Nucleic Acids Res. 34(6), 1685-91, (2006)

Loading...


4-Amino-1,8-naphthalimide-based Tröger's bases as high affinity DNA targeting fluorescent supramolecular scaffolds. Veale EB, Frimannsson DO, Lawler M, et al. Org. Lett. 11(18), 4040-3, (2009)

Loading...


Synthesis, photophysical, and DNA binding studies of fluorescent Tröger's base derived 4-amino-1,8-naphthalimide supramolecular clefts. Veale EB and Gunnlaugsson T J. Org. Chem. 75(16), 5513-25, (2010)

Loading...


Highly selective 4-amino-1,8-naphthalimide based fluorescent photoinduced electron transfer (PET) chemosensors for Zn(II) under physiological pH conditions. Parkesh R, Clive Lee T, and Gunnlaugsson T Org. Biomol. Chem. 5(2), 310-7, (2007)

Loading...


Demonstration of bidirectional photoinduced electron transfer (PET) sensing in 4-amino-1,8-naphthalimide based thiourea anion sensors. Veale EB, Tocci GM, Pfeffer FM, et al. Org. Biomol. Chem. 7(17), 3447-54, (2009)

Loading...


A highly selective colorimetric and ratiometric two-photon fluorescent probe for fluoride ion detection. Zhang JF, Lim CS, Bhuniya S, et al. Org. Lett. 13(5), 1190-3, (2011)

Loading...


[Effect of PARP-1 inhibitor 4-amino-1 ,8-naphthalimide on the on the sensitivity of adriamycin]. Jiang X, Liu S, Deng W, et al. Wei Sheng Yan Jiu 41(2), 173-9, (2012)

Loading...


PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility. Godon C, Cordelières FP, Biard D, et al. Nucleic Acids Res. 36(13), 4454-64, (2008)

Loading...


PARP-1 is involved in autophagy induced by DNA damage. Muñoz-Gámez JA, Rodríguez-Vargas JM, Quiles-Pérez R, et al. Autophagy 5(1), 61-74, (2009)

Loading...


Highly selective ratiometric fluorescent probe for Au3+ and its application to bioimaging. Choi JY, Kim GH, Guo Z, et al. Biosens. Bioelectron. 49, 438-41, (2013)

Loading...


Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks. Heacock ML, Stefanick DF, Horton JK, et al. DNA Repair (Amst.) 9(8), 929-36, (2010)

Loading...


A new polymerizable fluorescent PET chemosensor of fluoride (F-) based on naphthalimide-thiourea dye. Alaei P, Rouhani S, Gharanjig K, et al. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 90, 85-92, (2012)

Loading...


Luminescence targeting and imaging using a nanoscale generation 3 dendrimer in an in vivo colorectal metastatic rat model. Alcala MA, Kwan SY, Shade CM, et al. Nanomedicine: Nanotechnology, Biology, and Medicine 7(3), 249-58, (2011)

Loading...


Delayed activation of caspase-independent apoptosis during heart failure in transgenic mice overexpressing caspase inhibitor CrmA. Bae S, Siu PM, Choudhury S, et al. Am. J. Physiol. Heart Circ. Physiol. 299(5), H1374-81, (2010)

Loading...


Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. Horton JK, Stefanick DF, Gassman NR, et al. DNA Repair (Amst.) 12(9), 774-85, (2013)

Loading...


ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity. Horton JK, Stefanick DF, Kedar PS, et al. DNA Repair (Amst.) 6(6), 742-50, (2007)

Loading...


Inhibition of poly (ADP-ribose) polymerase-1 enhances doxorubicin activity against liver cancer cells. Muñoz-Gámez JA, Quiles-Pérez R, Ruiz-Extremera A, et al. Cancer Lett. 301(1), 47-56, (2011)

Loading...


Poly(ADP-ribose) polymerase inhibition reduces tumor necrosis factor-induced inflammatory response in rheumatoid synovial fibroblasts. García S, Bodaño A, Pablos JL, et al. Ann. Rheum. Dis. 67(5), 631-7, (2008)

Loading...


PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM. Carrozza MJ, Stefanick DF, Horton JK, et al. DNA Repair (Amst.) 8(11), 1264-72, (2009)

Loading...


Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition. Horton JK, Stefanick DF, Zeng JY, et al. DNA Repair (Amst.) 10(2), 225-34, (2011)

Loading...


Neuroprotective potential of combination of resveratrol and 4-amino 1,8 naphthalimide in experimental diabetic neuropathy: focus on functional, sensorimotor and biochemical changes. Sharma SS, Kumar A, Arora M, et al. Free Radic. Res. 43(4), 400-8, (2009)

Loading...


Protective effects of 4-amino1,8-napthalimide, a poly (ADP-ribose) polymerase inhibitor in experimental diabetic neuropathy. Sharma SS, Kumar A, and Kaundal RK Life Sci. 82(11-12), 570-6, (2008)

Loading...


Concurrent targeting of nitrosative stress-PARP pathway corrects functional, behavioral and biochemical deficits in experimental diabetic neuropathy. Negi G, Kumar A, and Sharma SS Biochem. Biophys. Res. Commun. 391(1), 102-6, (2010)

Loading...


Unexpected fluorescent behavior of a 4-amino-1,8-naphthalimide derived beta-cyclodextrin: conformation analysis and sensing properties. Zhong C, Mu T, Wang L, et al. Chem. Commun. (Camb.) (27), 4091-3, (2009)

Loading...


A stronger DNA damage-induced G2 checkpoint due to over-activated CHK1 in the absence of PARP-1. Lu HR, Wang X, and Wang Y Cell Cycle 5(20), 2364-70, (2006)

Loading...


Induction of apoptosis by the inhibitors of poly(ADP-ribose)polymerase in HeLa cells. Ghosh U and Bhattacharyya NP Mol. Cell Biochem. 320(1-2), 15-23, (2009)

Loading...


RegBook 1 (2), 2079:K

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?