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A1216 - N-Acetyl-Ile-Glu-Thr-Asp-al

A1216 Sigma

N-Acetyl-Ile-Glu-Thr-Asp-al

~99% (TLC), powder

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Synonym: Ac-IETD-CHO

Empirical Formula (Hill Notation) C₂₁H₃₄N₄O₁₀
Molecular Weight 502.52
MDL number MFCD01318858

N-Acetyl-Ile-Glu-Thr-Asp-al ~99% (TLC), powder

Properties

Related Categories	A to C, A-AM, Aldehydes, Apoptosis Enzymes, Apoptosis and Cell Cycle, Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Building Blocks, C13-C60, Carbonyl Compounds, Caspase 3, Caspase 8, Caspase Inhibitors, Caspase Inhibitors and Substrates, Caspases, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Chemical Synthesis, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Inhibitors, Organic Building Blocks, P to Q, Peptides and Proteins, Peptides for Cell Biology, Pro-caspase 3, Protease Inhibitor Specificity Index, Protease Inhibitors More...
assay	~99% (TLC)
form	powder
color	white
solubility	H₂O: soluble1 mg/mL
storage temp.	−20°C

Description

Biochem/physiol Actions

Caspase 8 inhibitor; blocks the cleavage of the 32 kDa caspase 3 precursor into the p12 and p20 subunits, thus blocking the formation of active caspase 3.

Price and Availability

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Related Papers

A sequential two-step mechanism for the production of mature p17:p12 form of caspase-3 in vitro.. Han, Z., et al. J. Biol. Chem. 272, 13432-13436, (1997)

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