|Related Categories||A to C, A-AM, Aldehydes, Apoptosis Enzymes, Apoptosis and Cell Cycle,|
|solubility||H2O: soluble1 mg/mL|
Caspase 8 inhibitor; blocks the cleavage of the 32 kDa caspase 3 precursor into the p12 and p20 subunits, thus blocking the formation of active caspase 3.
Bottomless glass bottle. Contents are inside inserted fused cone.
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~99% (HPLC), powder
≥90% (TLC), powder
Caspases (Cysteine dependant Aspartate Specific Proteases) form a family of closely related enzymes (family C14; clan CD) involved in regulating a type of cell death known as apoptosis, inflammatory ...
Keywords: Alkylations, Alzheimer Disease, Apoptosis, Cancer, Catalysis, Clinical, Diseases, Gene expression, Huntington Disease, Inflammation, Ligands, Parkinson Disease, Polymorphisms
Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay. Wenhua Chu et al Bioorg. Med. Chem. Lett. 21, 2192-7, (2011)
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