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A1224 Sigma

N-(4-Acetamidophenyl)indomethacinamide

≥98%, crystalline

Synonym: N-4AcetIA, N-(4-Acetamidophenyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide

  • Empirical Formula (Hill Notation) C27H24N3O4Cl

  • Molecular Weight 489.95

  •  MDL number MFCD02683236

  •  PubChem Substance ID 329770691

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Properties

Related Categories A to C, Application Index, Arachidonic Acid Cascade, Biochemicals and Reagents, Cancer Research,
InChI Key   CVMUUPNNEPVQCL-UHFFFAOYSA-N
assay   ≥98%
form   crystalline
solubility   DMSO: ≥15 mg/mL
  DMF: ≥23 mg/mL
absorption   λmax 267 nm
shipped in   wet ice
storage temp.   −20°C

Description

Biochem/physiol Actions

Potent and selective reversible COX-2 inhibitor. N-4-AcetIA inhibits human and ovine COX-2 with IC50 of 0.1 μM and 0.625 μM, respectively. About 400 times less potent as an inhibitor of human COX-1 and 80 times less potent as an inhibitor of ovine COX-1. Shows anti−inflammatory, antiangiogenic, and cancer chemopreventive activity in various experimental models.

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Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
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