Amastatin hydrochloride hydrate ≥97% (HPLC)

Properties

Related Categories	A - K, A-AM, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure Class, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Inhibits an Enzyme, L to O, Leucine aminopeptidase, cytosol, Leucine aminopeptidase, microsomal, Mechanism of Action, Miscellaneous Peptides, Peptides, Peptides and Proteins, Peptides for Cell Biology, Protease Inhibitor Specificity Index, Protease Inhibitors, Spectrum of Activity More...
assay	≥97% (HPLC)
solubility	methanol: soluble1 mM (Stock solution stable for 1 month at −20 °C. Working solution stable for 1 day.)
storage temp.	−20°C

Description

Biochem/physiol Actions

It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts angiotensin II to angiotensin III. Potentiates the CNS effects of vasopressin and oxytocin in vivo.¹

Effective concentration: 1-10 μM.

It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts angiotensin II to angiotensin III. Potentiates the CNS effects of vasopressin and oxytocin in vivo.¹Effective concentration: 1-10 μM.