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A1304 Sigma

β-Amanitin from Amanita phalloides

~90% (HPLC)

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Description

Biochem/physiol Actions

Toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but not RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis.

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α-Amanitin

from Amanita phalloides, ≥90% (HPLC), powder

suitable for fluorescence, ≥95.0% (HPCE)

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
Hazard Codes (Europe) 
T+
Risk Statements (Europe) 
Safety Statements (Europe) 
7-28-36/37/39-45
RIDADR 
UN 3462 6.1 / PGI
WGK Germany 
3
RTECS 
NJ8324000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

[Determination of amanitatoxins by HPLC]. Nishizawa C and Yamaura Y Chudoku. Kenkyu. 16(4), 441-5, (2003)

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Gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) in toxicological analysis. Studies on the detection of clobenzorex and its metabolites within a systematic toxicological analysis procedure by GC-MS and by immunoassay and studies on the detection of alpha- and beta-amanitin in urine by atmospheric pressure ionization electrospray LC-MS. Maurer HH, Kraemer T, Ledvinka O, et al. J. Chromatogr. B. Biomed. Sci. Appl. 689(1), 81-9, (1997)

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Validated electrospray liquid chromatographic-mass spectrometric assay for the determination of the mushroom toxins alpha- and beta-amanitin in urine after immunoaffinity extraction. Maurer HH, Schmitt CJ, Weber AA, et al. J. Chromatogr. B. Biomed. Sci. Appl. 748(1), 125-35, (2000)

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Determination of alpha-amanitin and beta-amanitin in human biological fluids by high-performance liquid chromatography. Jehl F, Gallion C, Birckel P, et al. Anal. Biochem. 149(1), 35-42, (1985)

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Strongly enhanced toxicity of the mushroom toxin alpha-amanitin by an amatoxin-specific Fab or monoclonal antibody. Faulstich H, Kirchner K, and Derenzini M Toxicon 26(5), 491-9, (1988)

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Determination of alpha- and beta-amanitin in clinical urine samples by Capillary Zone Electrophoresis. Robinson-Fuentes VA, Jaime-Sánchez JL, García-Aguilar L, et al. J. Pharm. Biomed. Anal. 47(4-5), 913-7, (2008)

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A highly sensitive and specific enzyme immunoassay for detection of beta-amanitin in biological fluids. Abuknesha RA and Maragkou A Anal. Bioanal. Chem 379(5-6), 853-60, (2004)

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Illumina-based de novo transcriptome sequencing and analysis of Amanita exitialis basidiocarps. Li P, Deng WQ, Li TH, et al. Gene 532(1), 63-71, (2013)

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Preparation of a beta-amanitin-concanavalin A conjugate of low toxicity. Zhelev Z, Zheleva A, and Halacheva K Toxicon 25(9), 981-7, (1987)

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Gene activity during germination of spores of the fern, Onoclea sensibilis. Cell-free translation analysis of mRNA of spores and the effect of alpha-amanitin on spore germination. Raghavan V J. Plant Physiol. 140(4), 434-40, (1992)

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Epidermal growth factor labeled beta-amanitin-poly-L-ornithine: preparation and evidence for specific cytotoxicity. Bermbach U and Faulstich H Biochemistry 29(29), 6839-45, (1990)

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Cytotoxicity on L1210 leukemic cells of beta-amanitin-concanavalin A and phallacidin-concanavalin A conjugates. Zhelev Z, Ilarionova M, Zheleva A, et al. Toxicon 28(11), 1360-3, (1990)

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Express method for detection of Amanita phalloides amanitine toxins. Vlaskin DN, Gainullina ET, Klyuster OV, et al. Bull. Exp. Biol. Med. 141(1), 110-1, (2006)

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Merck 14,373

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