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A1388 Sigma

Adenosine 5′-[γ-thio]triphosphate tetralithium salt

≥75%, powder

Synonym: ATP-γ-S, Adenosine 5′-(3-thiotriphosphate) tetralithium salt, Ado-5′-PPP[S]

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Properties

Related Categories Biochemicals and Reagents, Cofactors, Core Bioreagents, Enzymes, Inhibitors, and Substrates, Nucleosides and Nucleotides,
InChI Key   DWQFDOIBOYDYKH-KWIZKVQNSA-J
assay   ≥75%
form   powder
color   white
solubility   H2O: soluble25 mg/mL
shipped in   dry ice
storage temp.   −20°C

Description

Biochem/physiol Actions

P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; can substitute for ATP in kinase reactions yielding thiophosphorylated proteins that are resistant to protein phosphatases.

Other Notes

Non-hydrolyzable ATP analog

Packaging

1, 5 mg in glass bottle

25 mg in poly bottle

Application

Adenosine 5′-[γ-thio]triphosphate (ATP-γ-S) is widely used as a non-hydrolyzed ATP analogue for studies on the effects of ATP binding to ATP sites in a wide range of processes including extracellular functions. ATP- γ-S is a P2 purinergic agonist which increases the activity of Ca2+-activated K+ channels. ATP- γ-S can substitute for ATP in kinase reactions yielding thiophosphorylated proteins that are resistant to protein phosphatases and modulate the ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome. ATP-γ -S differentially modulates Toll-like receptor 4-mediated cell survival and death.

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Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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