5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5′-monophosphate ≥93%

Properties

Related Categories	Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart, Metabolomics, Nucleotide
assay	≥93%
storage temp.	−20°C

Description

Biochem/physiol Actions

A 5′-phosphorylated analog of cell permeable AICAR that mimics AMP. AMPK (AMP-activated protein kinase) activator.

Application

AICAR monophosphate is a 5′′-phosphorylated analog of cell permeable AICAR that mimics AMP. AICAR is an adenosine monophophate (AMP)-activated protein kinase (AMPK) activator/agonist.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A1393.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Price and Availability

Related Papers

AMPK activation enhances PPARγ activity to inhibit cardiac hypertrophy via ERK1/2 MAPK signaling pathway. Meng R, Pei Z, Zhang A, et al. Arch. Biochem. Biophys. 511, 1-7, (2011)

Documents

Certificate of Analysis

Certificate of Origin

Safety Information

Personal Protective Equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany	3

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

Mitochondrial Dysfunction and Metabolic Defects

Defects in mitochondrial function are associated with insulin resistance in both human and animal studies. Insulin resistance is associated with a decrease in the number, oxidative capacity, size, an...
Keywords: Acetylations, Apoptosis, Cancer, Carboxylations, Catalysis, Citric Acid Cycle, Decarboxylations, Degradations, Diabetes, Enzyme-linked immunosorbent assay, Glycolysis, Immunofluorescence, Immunohistochemistry, Lipid Metabolism, Metabolism, Metabolites, Neurotransmitters, Obesity, Oxidations, Phosphorylations, Physiological Processes, Transcription, Transduction, Transfection, Western blot

Papers

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AMPK activation enhances PPARγ activity to inhibit cardiac hypertrophy via ERK1/2 MAPK signaling pathway. Meng R, Pei Z, Zhang A, et al. Arch. Biochem. Biophys. 511, 1-7, (2011)

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Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver. Jung EJ, Kwon SW, et al. J. Lipid Res. 52, 1617-1625, (2011)

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Acute therapeutic use of 5-aminoimidazole-4-carboxamide ribonucleoside extends survival interval in response to severe hemorrhagic shock. Smith Sonneborn J, Rutten M. Shock 36, 191-195, (2011)

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Down-regulation of the ubiquitin-proteasome proteolysis system by amino acids and insulin involves the adenosine monophosphate-activated protein kinase and mammalian target of rapamycin pathways in rat hepatocytes. Chotechuang N, Azzout-Marniche D, et al. Amino Acids 41, 457-468, (2011)

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AMP-activated protein kinase inhibits TGF-β-induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300. Lim JY, Oh MA, Kim WH, et al. J. Cell Physiol., (2011)