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A 5′-phosphorylated analog of cell permeable AICAR that mimics AMP. AMPK (AMP-activated protein kinase) activator.
AICAR monophosphate is a 5′′-phosphorylated analog of cell permeable AICAR that mimics AMP. AICAR is an adenosine monophophate (AMP)-activated protein kinase (AMPK) activator/agonist.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A1393.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
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≥98% (HPLC), powder
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Keywords: Acetylations, Apoptosis, Cancer, Carboxylations, Catalysis, Citric Acid Cycle, Decarboxylations, Degradations, Diabetes, Enzyme-linked immunosorbent assay, Glycolysis, Immunofluorescence, Immunohistochemistry, Lipid Metabolism, Metabolism, Metabolites, Neurotransmitters, Obesity, Oxidations, Phosphorylations, Physiological Processes, Transcription, Transduction, Transfection, Western blot
Down-regulation of the ubiquitin-proteasome proteolysis system by amino acids and insulin involves the adenosine monophosphate-activated protein kinase and mammalian target of rapamycin pathways in rat hepatocytes. Chotechuang N, Azzout-Marniche D, et al. Amino Acids 41, 457-468, (2011)
The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells. Rosilio C, Lounnas N, Nebout M, et al. Cancer Lett. 336(1), 114-26, (2013)
Combination therapy with 5-amino-4-imidazolecarboxamide riboside and arsenic trioxide in acute myeloid leukemia cells involving AMPK/TSC2/mTOR pathway. Chen L, Han F, Qu H, et al. Pharmazie 68(2), 117-23, (2013)
Central glucagon-like peptide 1 receptor-induced anorexia requires glucose metabolism-mediated suppression of AMPK and is impaired by central fructose. Burmeister MA, Ayala J, Drucker DJ, et al. Am. J. Physiol. Endocrinol. Metab. 304(7), E677-85, (2013)
A HPLC method for simultaneous determination of 5-aminoimidazole-4-carboxamide riboside and its active metabolite 5-aminoimidazole-4-carboxamide ribotide in tumor-bearing nude mice plasma and its application to pharmacokinetics study. Cheng X, Guo L, Li Z, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 915-916, 64-70, (2013)
Inhibition of AMP-activated protein kinase accentuates lipopolysaccharide-induced lung endothelial barrier dysfunction and lung injury in vivo. Xing J, Wang Q, Coughlan K, et al. Am. J. Pathol. 182(3), 1021-30, (2013)
Aminoimidazole carboxamide ribonucleotide (AICAR) inhibits the growth of retinoblastoma in vivo by decreasing angiogenesis and inducing apoptosis. Theodoropoulou S, Brodowska K, Kayama M, et al. PLoS ONE 8(1), e52852, (2013)
Aberrant endoplasmic reticulum stress in vascular smooth muscle increases vascular contractility and blood pressure in mice deficient of AMP-activated protein kinase-α2 in vivo. Liang B, Wang S, Wang Q, et al. Arterioscler. Thromb. Vasc. Biol. 33(3), 595-604, (2013)
Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy. Huang H, Kang R, Wang J, et al. Autophagy 9(2), 175-95, (2013)
Store-operated Ca2+ entry (SOCE) induced by protease-activated receptor-1 mediates STIM1 protein phosphorylation to inhibit SOCE in endothelial cells through AMP-activated protein kinase and p38β mitogen-activated protein kinase. Sundivakkam PC, Natarajan V, Malik AB, et al. J. Biol. Chem. 288(23), 17030-41, (2013)
Inhibition of the LKB1-AMPK pathway by the Epstein-Barr virus-encoded LMP1 promotes proliferation and transformation of human nasopharyngeal epithelial cells. Lo AK, Lo KW, Ko CW, et al. J. Pathol. 230(3), 336-46, (2013)
AICAR administration ameliorates hypertension and angiogenic imbalance in a model of preeclampsia in the rat. Banek CT, Bauer AJ, Needham KM, et al. Am. J. Physiol. Heart Circ. Physiol. 304(8), H1159-65, (2013)
AMP-activated protein kinase activation by 5-aminoimidazole-4-carbox-amide-1-β-D-ribofuranoside (AICAR) reduces lipoteichoic acid-induced lung inflammation. Hoogendijk AJ, Pinhanços SS, van der Poll T, et al. J. Biol. Chem. 288(10), 7047-52, (2013)
AMP-activated protein kinase inhibits vascular smooth muscle cell proliferation and migration and vascular remodeling following injury. Stone JD, Narine A, Shaver PR, et al. Am. J. Physiol. Heart Circ. Physiol. 304(3), H369-81, (2013)
Effects of AMPK activation and combined treatment with AMPK activators and somatostatin on hormone secretion and cell growth in cultured GH-secreting pituitary tumor cells. Tulipano G, Faggi L, Losa M, et al. Mol. Cell. Endocrinol. 365(2), 197-206, (2013)
The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell proliferation and apoptosis via an AMPK/mTOR/P70S6K signaling pathway. Miao XY, Gu ZY, Liu P, et al. Peptides 39, 71-9, (2013)
AMP-activated protein kinase inhibits TGF-β-induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300. Lim JY, Oh MA, Kim WH, et al. J. Cell Physiol., (2011)
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