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A1663 Sigma

Atrial Natriuretic Peptide human

≥97% (HPLC)

Synonym: ANF 1-28, hANF

  • CAS Number 91917-63-4

  • Empirical Formula (Hill Notation) C127H203N45O39S3

  • Molecular Weight 3080.44

  •  MDL number MFCD00076226

  •  PubChem Substance ID 24890580

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Guanylate Cyclase Activators, Miscellaneous Peptides, Natriuretic Peptides,
InChI Key   KGZJRXKGJRJKCB-UHFFFAOYSA-N
assay   ≥97% (HPLC)
storage temp.   −20°C
Gene Information   human ... NPPA(4878)

Description

Amino Acid Sequence

Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr [Disulfide bridge: 7-23]

Other Notes

Lyophilized from 0.1% TFA in H2O

Biochem/physiol Actions

Atrial natriuretic peptide (ANP) is synthesized in myoendocrine cells of the heart from which it is released into the circulation. It exerts natriuretic, diuretic, and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure homeostasis.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Antihypertensive Agents

Download BioFiles v7 n5 (3.18 Mb PDF) Back to Pharmaceutical Drugs and Drug Candidates homepage
Sami Barghshoon
BioFiles v7 n5, 2012, 5–20
Keywords: AGE, Antihypertensives, Cardiovascular, Clinical, Diuretics, Pharmaceutical, Reductions

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