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A166 Sigma

Sp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt hydrate

≥98% (HPLC), solid

Synonym: Sp-Cyclic 3′,5′-hydrogen phosphorothioate adenosine hydrate, Sp-cAMPS triethylammonium salt

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Properties

Related Categories A-AM, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   OXIPZMKSNMRTIV-BIQAKYJPSA-N
assay   ≥98% (HPLC)
form   solid
optical activity   [α]22/D −25.43°, c = 0.99 in H2O(lit.)
color   white
solubility   H2O: soluble
storage temp.   −20°C

Description

Biochem/physiol Actions

Sp-Diastereomer of adenosine 3′,5′-cyclic monophosphorothioate is a potent, membrane-permeable activator of cAMP dependent protein kinase I and II that mimics the effects of cAMP as a second messenger in numerous systems while being resistant to cyclic nucleotide phosphodiesterases; exhibits greater specificity and affinity than forskolin and cAMP analogs such as dibutyryl-cAMP.

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RIDADR 
NONH for all modes of transport
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3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

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