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  • A1824 - N-Acetyl-5-hydroxytryptamine


A1824 Sigma


≥99% (TLC), powder

Synonym: N-Acetylserotonin, Normelatonin


Related Categories Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies,
assay   ≥99% (TLC)
form   powder
color   white
mp   120-122 °C(lit.)
solubility   ethanol: soluble50 mg/mL
storage temp.   2-8°C
Gene Information   human ... MTNR1A(4543), MTNR1B(4544)



1 g in poly bottle

100, 250 mg in poly bottle

Biochem/physiol Actions

Immediate precursor of melatonin. It is formed from serotonin and acetyl-CoA in a reaction catalyzed by serotonin N-acetyl transferase, the rate-limiting enzyme in melatonin biosynthesis. This indoleamine is a weak agonist at melatonin receptors, and has moderate effects on G-protein stimulation and inhibition of cAMP accumulation.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®,1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

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