• USA Home
  • A1895 - Aurintricarboxylic acid

EMAIL THIS PAGE TO A FRIEND
A1895 Sigma

Aurintricarboxylic acid

practical grade, ≥85% (titration), powder

Synonym: ATA

Purchase

Properties

Related Categories Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience, DNA Repair Regulators, DNA metabolism More...
grade   practical grade
InChI Key   GIXWDMTZECRIJT-UHFFFAOYSA-N
assay   ≥85% (titration)
form   powder
color   dark red
mp   300 °C(lit.)
solubility   1 M NH4OH: soluble10 mg/mL

Description

Biochem/physiol Actions

Readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. Inhibits apoptosis. It prevents down-regulation of Ca2+ -impermeable GluR2 receptors and inhibits calpain, a Ca2+ -activated protease that is activated during apoptosis.

Packaging

5, 25 g in glass bottle

Application

• Aurintricarboxylic acid has been used to show its anticryptosporidial activity against Cryptosporidium parvum.
• It has been used as a test substance to identify inhibitors against coronavirus N7-MTases (guanine-N7-methyltransferase).
• It has been used as a ribonuclease inhibitor.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
GU4790000
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?