γ-Aminobutyric acid

Papers

The GABAergic System In The Retina Of Neonate And Adult Octodon Degus, Studied By Immunohistochemistry And Electroretinography. Delgado, L.M., et al. J. Comp. Neurol. 514, 459-72, (2009)

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Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds. Marco L Lolli et al J. Med. Chem. 49, 4442-6, (2006)

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3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J. Med. Chem. 49, 5571, (2006)

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Novel 3-O-glycosyl-3-demethylthiocolchicines as ligands for glycine and gamma-aminobutyric acid receptors. Maria Luisa Gelmi et al J. Med. Chem. 50, 2245-8, (2007)

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5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists. Christian Madsen et al J. Med. Chem. 50, 4147-61, (2007)

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Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor. Anders A Jensen et al J. Med. Chem. 50, 4616-29, (2007)

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Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. Zhan-Heng Qi et al J. Biol. Chem. 282, 33052-63, (2007)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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A mutual prodrug ester of GABA and perphenazine exhibits antischizophrenic efficacy with diminished extrapyramidal effects. Abraham Nudelman et al J. Med. Chem. 51, 2858-62, (2008)

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Novel gamma-aminobutyric acid rho1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships. Rohan J Kumar et al J. Med. Chem. 51, 3825-40, (2008)

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Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. Cheryl A Grice et al J. Med. Chem. 51, 4150-69, (2008)

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Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding site. M. Jansen, et al., J. Med. Chem. 51, 4430-4448, (2008)

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cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia. Huaqing Liu et al J. Med. Chem. 51, 7094-8, (2008)

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Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors. Tina Hinton et al Bioorg. Med. Chem. Lett. 18, 402-4, (2008)

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Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Shuang Chang et al Nat. Chem. Biol. 4, 256-63, (2008)

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Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies. Gamze Bora-Tatar et al Bioorg. Med. Chem. 17, 5219-28, (2009)

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N-methyl phenylalanine-rich peptides as highly versatile blood-brain barrier shuttles. Morteza Malakoutikhah et al J. Med. Chem. 53, 2354-63, (2010)

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Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships. Shigeo Hayashi et al Bioorg. Med. Chem. 18, 7675-99, (2010)

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Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1). Iris Thondorf et al Bioorg. Med. Chem. 19, 6409-18, (2011)

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Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors. Silke Hack et al Eur. J. Med. Chem. 46, 1483-98, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. Schwartz-Bloom, R.D., Sah, R. J. Neurochem. 77, 353, (2001)

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Merck 14,430

Beil. 4,IV,2600

FT-IR 2 (1), 917:D / FT-IR 1 (1), 577:C / IR-Spectra (3), 345:C / IR-Spectra (2), 307:G / NMR-Reference 2 (1), 487:D / RegBook 1 (1), 659:A / Sax 6, 2236 / Sigma FT-IR 1 (1), 32:D / Structure Index 1, 97:B:6