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A2408 Sigma

S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt

from yeast (L-methionine enriched), ≥80% (HPLC), ≥80% (spectrophotometric assay)

Synonym: AdoMet, SAM p-toluenesulfonate salt

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Properties

Related Categories Amino Acid, Cell Biology, Coenzymes and Cofactors, Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart,
biological source   from yeast (L-methionine enriched)
InChI Key   VHPOFDUCFKOUHV-XKGORWRGSA-N
assay   ≥80% (HPLC)
  ≥80% (spectrophotometric assay)
composition   p-Toluenesulfonate content, 1.6-4.4 mol/mol
solubility   H2O: soluble100 mg/mL
shipped in   dry ice
storage temp.   −20°C

Description

Biochem/physiol Actions

S-(5′-Adenosyl)-L-methionine (SAM) is anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinoma (HCC), HepG2 cells and colon cancer cells.

Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.

Caution

This material is unstable at room temperature.

Packaging

25, 100, 500 mg in poly bottle

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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